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    Jan 17, 2021
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    Short Report: Molecular Markers Associated with Plasmodium Falciparum Resistance to Sulfadoxine-Pyrimethamine in the Democratic Republic of Congo.

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    Authors
    Cohuet, S
    Bonnet, M
    Van Herp, M
    Van Overmeir, C
    D'Alessandro, U
    Guthmann, J P P
    Affiliation
    Epicentre, Paris, France; Médecins Sans Frontières, Brussels, Belgium; Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
    Issue Date
    2006-07
    
    Metadata
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    Journal
    The American Journal of Tropical Medicine and Hygiene
    Abstract
    Sulfadoxine-pyrimethamine (SP) is the first line antimalarial treatment in the Democratic Republic of Congo. Using polymerase chain reaction, we assessed the prevalence of mutations in the dihydrofolate reductase (dhfr) (codons 108, 51, 59) and dihydropteroate synthase (dhps) (codons 437, 540) genes of Plasmodium falciparum, which have been associated with resistance to pyrimethamine and sulfadoxine, respectively. Four hundred seventy-four patients were sampled in Kilwa (N = 138), Kisangani (N = 112), Boende (N = 106), and Basankusu (N = 118). The proportion of triple mutations dhfr varied between sites but was always > 50%. The proportion of dhps double mutations was < 20%, with some sites as low as 0.9%. A quintuple mutation was present in 12.8% (16/125) samples in Kilwa; 11.9% (13/109) in Kisangani, 2.9% (3/102) in Boende, and 0.9% (1/112) in Basankusu. These results suggest high resistance to pyrimethamine alone or combined with sulfadoxine. Adding artesunate to SP does not seem a valid alternative to the current monotherapy.
    URI
    http://hdl.handle.net/10144/18354
    PubMed ID
    16837723
    Additional Links
    http://www.ajtmh.org
    http://www.ajtmh.org
    Language
    en
    ISSN
    0002-9637
    Collections
    Laboratory

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