• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    Apr 17, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Accuracy of immunological criteria for identifying virological failure in children on antiretroviral therapy - The IeDEA Southern Africa Collaboration.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Davies Accuracy Imm Crit South ...
    Size:
    57.60Kb
    Format:
    PDF
    Download
    Authors
    Davies, Mary-Ann
    Boulle, Andrew
    Eley, Brian
    Moultrie, Harry
    Technau, Karl
    Rabie, Helena
    van Cutsem, Gilles
    Giddy, Janet
    Wood, Robin
    Egger, Matthias
    Keiser, Olivia
    Show allShow less
    Affiliation
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa  Red Cross Children's Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa  Wits Institute for Sexual Reproductive Health, HIV & Related Diseases, University of the Witwatersrand, Johannesburg, South Africa  Empilweni Service and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa  Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa  Khayelitsha ART Programme and Médecins Sans Frontières, Khayelitsha, South Africa  McCord Hospital, Durban, South Africa  Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa  Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
    Issue Date
    2011-08-11
    
    Metadata
    Show full item record
    Journal
    Tropical Medicine & International Health : TM & IH
    Abstract
    Objectives  To determine the diagnostic accuracy of World Health Organization (WHO) 2010 and 2006 as well as United States Department of Health and Human Services (DHHS) 2008 definitions of immunological failure for identifying virological failure (VF) in children on antiretroviral therapy (ART). Methods  Analysis of data from children (<16 years at ART initiation) at South African ART sites at which CD4 count/per cent and HIV-RNA monitoring are performed 6-monthly. Incomplete virological suppression (IVS) was defined as failure to achieve ≥1 HIV-RNA ≤400 copies/ml between 6 and 15 months on ART and viral rebound (VR) as confirmed HIV-RNA ≥5000 copies/ml in a child on ART for ≥18 months who had achieved suppression during the first year on treatment. Results  Among 3115 children [median (interquartile range) age 48 (20-84) months at ART initiation] on treatment for ≥1 year, sensitivity of immunological criteria for IVS was 10%, 6% and 26% for WHO 2006, WHO 2010 and DHHS 2008 criteria, respectively. The corresponding positive predictive values (PPV) were 31%, 20% and 20%. Diagnostic accuracy for VR was determined in 2513 children with ≥18 months of follow-up and virological suppression during the first year on ART with sensitivity of 5% (WHO 2006/2010) and 27% (DHHS 2008). PPV results were 42% (WHO 2010), 43% (WHO 2006) and 20% (DHHS 2008). Conclusion  Current immunological criteria are unable to correctly identify children failing ART virologically. Improved access to viral load testing is needed to reliably identify VF in children.
    URI
    http://hdl.handle.net/10144/204589
    DOI
    10.1111/j.1365-3156.2011.02854.x
    PubMed ID
    21834797
    Language
    en
    ISSN
    1365-3156
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3156.2011.02854.x
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

    Related articles

    • The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure.
    • Authors: Davies MA, Boulle A, Technau K, Eley B, Moultrie H, Rabie H, Garone D, Giddy J, Wood R, Egger M, Keiser O, IeDEA Southern Africa Collaboration.
    • Issue date: 2012 Nov
    • Viral load versus CD4⁺ monitoring and 5-year outcomes of antiretroviral therapy in HIV-positive children in Southern Africa: a cohort-based modelling study.
    • Authors: Salazar-Vizcaya L, Keiser O, Karl Technau, Davies MA, Haas AD, Blaser N, Cox V, Eley B, Rabie H, Moultrie H, Giddy J, Wood R, Egger M, Estill J
    • Issue date: 2014 Oct 23
    • Detecting virological failure in HIV-infected Tanzanian children.
    • Authors: Mgelea EM, Kisenge R, Aboud S
    • Issue date: 2014 Jun 26
    • Accuracy of WHO CD4 cell count criteria for virological failure of antiretroviral therapy.
    • Authors: Keiser O, MacPhail P, Boulle A, Wood R, Schechter M, Dabis F, Sprinz E, Egger M, ART-LINC Collaboration of the International Databases to Evaluate AIDS (IeDEA).
    • Issue date: 2009 Oct
    • Performance of immunological response in predicting virological failure.
    • Authors: Ingole N, Mehta P, Pazare A, Paranjpe S, Sarkate P
    • Issue date: 2013 Mar
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.