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    Jan 19, 2021
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    Avidity of serogroup A meningococcal IgG antibodies after immunization with different doses of a tetravalent A/C/Y/W135 polysaccharide vaccine

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    Authors
    Bårnes, G K
    Naess, L M
    Rosenqvist, E
    Guerin, P J
    Caugant, D A
    Affiliation
    Department of Bacteriology and Immunology, Norwegian Institute of Public Health, Oslo, Norway; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Department of Infectious Disease Epidemiology, Norwegian Institute of Public Health, Oslo, Norway; Epicentre, Paris, France; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, CCVTM, Oxford, UK; Department of International Health, University of Oslo, Oslo, Norway
    Issue Date
    2011-06-08
    
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    Journal
    Scandinavian Journal of Immunology
    Abstract
    In the absence of an affordable conjugate meningococcal vaccine, mass vaccination campaigns with polysaccharide vaccines are the means to control meningitis epidemics in sub-Saharan Africa. Facing global vaccine shortage, the use of reduced doses, which have been shown to be protective by serum bactericidal activity, can save many lives. In this study, we investigated the antibody responses and avidity of IgG antibodies evoked against the serogroup A capsule of Neisseria meningitidis by different doses of an A/C/Y/W135 polysaccharide vaccine. Volunteers in Uganda were vaccinated with 1/10, 1/5 or a full dose (50 μg) and revaccinated with a full dose after 1 year. Specific IgG geometric mean concentrations and geometric mean avidity indices (GMAI) were determined by a modified enzyme-linked immunosorbent assay (ELISA) using thiocyanate as a chaotropic agent. After vaccination with 1/10 or 1/5 doses, the GMAI increased from 1 month to 1 year. One year following the initial dose, the GMAI levels were higher in the arm receiving reduced doses than for the arm receiving a full dose. Following the second full dose, avidity indices equalized at approximately the same level in the three arms. Although there are practical challenges to the use of reduced doses in the field, our findings suggest that reduced doses of polysaccharide vaccine are able to elicit antibodies of as good avidity against serogroup A polysaccharide as a full dose.
    Publisher
    Blackwell
    URI
    http://hdl.handle.net/10144/221031
    DOI
    10.1111/j.1365-3083.2011.02535.x
    PubMed ID
    21332570
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2011.02535.x/abstract
    Type
    Article
    Language
    en
    ISSN
    1365-3083
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3083.2011.02535.x
    Scopus Count
    Collections
    Vaccination

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