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    Mar 02, 2021
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    Epidemiological Support for a Multifactorial Aetiology of Kashin-Beck Disease in Tibet.

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    Authors
    Suetens, C
    Moreno-Reyes, R
    Chasseur, C
    Mathieu, F
    Begaux, F
    Haubruge, E
    Durand, M
    Nève, J
    Vanderpas, J
    Affiliation
    Médecins Sans Frontières, Brussels, Belgium. carl.suetens@ihe.be
    Issue Date
    2001
    
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    Journal
    International Orthopaedics
    Abstract
    We carried out a cross-sectional study in 12 rural villages in order to identify the risk factors for Kashin-Beck disease in Tibet. Children aged 5-15 years (n=575) were examined and their corresponding houses were visited. Samples were collected in order to study fungal contamination of stored grain and the organic matter content of drinking water. Multivariate analysis was performed using logistic regression and population attributable fractions were computed to estimate the impact of each factor. The following variables were independently associated with the disease: age, gender, low socio-economic status, indicators of a poorly diversified diet, iodine deficiency and small water container size (with higher organic matter levels in small containers). Selenium deficiency was severe in all study subjects. The degree of fungal contamination of barley grain was related to the highest percentage of cases (65%) in a sample of the study population. Higher urinary iodine levels were not associated with decreasing prevalence rates when Alternaria sp. was isolated. The data that we report supports the hypothesis that Kashin-Beck disease occurs as a consequence of oxidative damage to cartilage and bone cells when associated with decreased antioxidant defence. Another mechanism that may coexist is bone remodelling stimulated by thyroid hormones whose actions can be blocked by certain mycotoxins.
    Publisher
    Springer
    URI
    http://hdl.handle.net/10144/22206
    PubMed ID
    11482537
    Language
    en
    ISSN
    0341-2695
    Collections
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