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dc.contributor.authorSuetens, C
dc.contributor.authorMoreno-Reyes, R
dc.contributor.authorChasseur, C
dc.contributor.authorMathieu, F
dc.contributor.authorBegaux, F
dc.contributor.authorHaubruge, E
dc.contributor.authorDurand, M
dc.contributor.authorNève, J
dc.contributor.authorVanderpas, J
dc.date.accessioned2008-04-03T14:05:30Z
dc.date.available2008-04-03T14:05:30Z
dc.date.issued2001
dc.identifier.citationEpidemiological Support for a Multifactorial Aetiology of Kashin-Beck Disease in Tibet. 2001, 25 (3):180-7notInt Orthopen
dc.identifier.issn0341-2695
dc.identifier.pmid11482537
dc.identifier.urihttp://hdl.handle.net/10144/22206
dc.description.abstractWe carried out a cross-sectional study in 12 rural villages in order to identify the risk factors for Kashin-Beck disease in Tibet. Children aged 5-15 years (n=575) were examined and their corresponding houses were visited. Samples were collected in order to study fungal contamination of stored grain and the organic matter content of drinking water. Multivariate analysis was performed using logistic regression and population attributable fractions were computed to estimate the impact of each factor. The following variables were independently associated with the disease: age, gender, low socio-economic status, indicators of a poorly diversified diet, iodine deficiency and small water container size (with higher organic matter levels in small containers). Selenium deficiency was severe in all study subjects. The degree of fungal contamination of barley grain was related to the highest percentage of cases (65%) in a sample of the study population. Higher urinary iodine levels were not associated with decreasing prevalence rates when Alternaria sp. was isolated. The data that we report supports the hypothesis that Kashin-Beck disease occurs as a consequence of oxidative damage to cartilage and bone cells when associated with decreased antioxidant defence. Another mechanism that may coexist is bone remodelling stimulated by thyroid hormones whose actions can be blocked by certain mycotoxins.
dc.language.isoenen
dc.publisherSpringeren
dc.rightsArchived on this site with kind permission of Springer Science+Business Mediaen
dc.subject.meshAdolescenten
dc.subject.meshAgricultureen
dc.subject.meshCerealsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshFood Microbiologyen
dc.subject.meshFood Supplyen
dc.subject.meshHumansen
dc.subject.meshIodineen
dc.subject.meshLogistic Modelsen
dc.subject.meshMaleen
dc.subject.meshOsteoarthritisen
dc.subject.meshRisk Factorsen
dc.subject.meshRural Populationen
dc.subject.meshSeleniumen
dc.subject.meshSocioeconomic Factorsen
dc.subject.meshTibeten
dc.subject.meshWater Supplyen
dc.titleEpidemiological Support for a Multifactorial Aetiology of Kashin-Beck Disease in Tibet.en
dc.contributor.departmentMédecins Sans Frontières, Brussels, Belgium. carl.suetens@ihe.been
dc.identifier.journalInternational Orthopaedicsen
refterms.dateFOA2019-03-04T09:45:28Z
html.description.abstractWe carried out a cross-sectional study in 12 rural villages in order to identify the risk factors for Kashin-Beck disease in Tibet. Children aged 5-15 years (n=575) were examined and their corresponding houses were visited. Samples were collected in order to study fungal contamination of stored grain and the organic matter content of drinking water. Multivariate analysis was performed using logistic regression and population attributable fractions were computed to estimate the impact of each factor. The following variables were independently associated with the disease: age, gender, low socio-economic status, indicators of a poorly diversified diet, iodine deficiency and small water container size (with higher organic matter levels in small containers). Selenium deficiency was severe in all study subjects. The degree of fungal contamination of barley grain was related to the highest percentage of cases (65%) in a sample of the study population. Higher urinary iodine levels were not associated with decreasing prevalence rates when Alternaria sp. was isolated. The data that we report supports the hypothesis that Kashin-Beck disease occurs as a consequence of oxidative damage to cartilage and bone cells when associated with decreased antioxidant defence. Another mechanism that may coexist is bone remodelling stimulated by thyroid hormones whose actions can be blocked by certain mycotoxins.


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