embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation
Cox, H S
Karimovich, H A
AffiliationMolecular Mycobacteriology, Research Center Borstel, Germany; Macfarlane Burnet Institute for Medical Research and Public Health, Australia; Medecins Sans Frontieres, Uzbekistan; Ministry of Health, Uzbekistan; Medecins Sans Frontieres, Germany; Department of Pneumology, Medical School Hannover (MHH), Germany; National Reference Center for Mycobacteria, Research Center Borstel, Germany
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AbstractMechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development.