embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation
Authors
Plinke, CCox, H S
Zarkua, N
Karimovich, H A
Braker, K
Diel, R
Rüsch-Gerdes, S
Feuerriegel, S
Niemann, S
Affiliation
Molecular Mycobacteriology, Research Center Borstel, Germany; Macfarlane Burnet Institute for Medical Research and Public Health, Australia; Medecins Sans Frontieres, Uzbekistan; Ministry of Health, Uzbekistan; Medecins Sans Frontieres, Germany; Department of Pneumology, Medical School Hannover (MHH), Germany; National Reference Center for Mycobacteria, Research Center Borstel, GermanyIssue Date
2010-04-28Submitted date
2011-03-10
Metadata
Show full item recordAbstract
Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development.PubMed ID
20427375Additional Links
http://jac.oxfordjournals.org/content/65/7/1359.abstractType
ArticleLanguage
enISSN
1460-2091ae974a485f413a2113503eed53cd6c53
10.1093/jac/dkq120
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