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    Jan 16, 2021
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    embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation

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    Authors
    Plinke, C
    Cox, H S
    Zarkua, N
    Karimovich, H A
    Braker, K
    Diel, R
    Rüsch-Gerdes, S
    Feuerriegel, S
    Niemann, S
    Affiliation
    Molecular Mycobacteriology, Research Center Borstel, Germany; Macfarlane Burnet Institute for Medical Research and Public Health, Australia; Medecins Sans Frontieres, Uzbekistan; Ministry of Health, Uzbekistan; Medecins Sans Frontieres, Germany; Department of Pneumology, Medical School Hannover (MHH), Germany; National Reference Center for Mycobacteria, Research Center Borstel, Germany
    Issue Date
    2010-04-28
    Submitted date
    2011-03-10
    
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    Journal
    Journal of Antimicrobial Chemotherapy
    Abstract
    Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development.
    URI
    http://hdl.handle.net/10144/225986
    DOI
    10.1093/jac/dkq120
    PubMed ID
    20427375
    Additional Links
    http://jac.oxfordjournals.org/content/65/7/1359.abstract
    Type
    Article
    Language
    en
    ISSN
    1460-2091
    ae974a485f413a2113503eed53cd6c53
    10.1093/jac/dkq120
    Scopus Count
    Collections
    TB

    entitlement

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