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    Feb 24, 2021
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    Safety and Effectiveness of Amphotericin B Deoxycholate for the Treatment of Visceral Leishmaniasis in Uganda.

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    Authors
    Mueller, Y
    Nguimfack, A
    Cavailler, P
    Couffignal, S
    Rwakimari, J B
    Loutan, L
    Chappuis, F
    Affiliation
    Médecins Sans Frontières, Swiss Section, Rue de Lausanne 78, 1202 Geneva, Switzerland. yolanda.mueller@freesurf.ch
    Issue Date
    2008-01
    
    Metadata
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    Journal
    Annals of Tropical Medicine and Parasitology
    Abstract
    Between September 2003 and April 2004, the supply of antimonial drugs to Amudat Hospital, in north-eastern Uganda, was interrupted and all cases of visceral leishmaniasis presenting at the hospital could only be treated with amphotericin B deoxycholate (AmB). This allowed the safety and effectiveness of the AmB to be evaluated, in comparison with an historical cohort of patients treated, at the same hospital, with meglumine antimoniate (Sb(V)). Demographic and clinical data were collected before and after treatment. Adverse effects were recorded passively in all the subjects, and actively, using a standardized questionnaire, in a sub-group of the patients given AmB. The in hospital case-fatality 'rates' were 4.8% [95% confidence interval (CI) = 2.4%-8.8%] among the 210 patients treated with AmB and 3.7% (CI = 1.4%-7.9%) among the 161 patients treated with Sb(V) (P>0.20). Adverse effects requiring treatment interruption were rare in both cohorts. Treatment failures (i.e. non-responses or relapses) were observed in 2.9% (CI = 1.2%-6.4%) of the patients treated with AmB and 1.2% (CI = 0.1%-4.4%) of the patients treated with Sb(V) (P>0.20). For the treatment of visceral leishmaniasis in Uganda, AmB therefore had a similar effectiveness and safety profile to that of meglumine antimoniate.
    Publisher
    Maney Publishing
    URI
    http://hdl.handle.net/10144/23215
    DOI
    10.1179/136485908X252142
    PubMed ID
    18186974
    Additional Links
    http://www.maney.co.uk/journals/atmp
    Language
    en
    ISSN
    0003-4983
    ae974a485f413a2113503eed53cd6c53
    10.1179/136485908X252142
    Scopus Count
    Collections
    Leishmaniasis/Kala Azar

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