Safety and Effectiveness of Amphotericin B Deoxycholate for the Treatment of Visceral Leishmaniasis in Uganda.
Affiliation
Médecins Sans Frontières, Swiss Section, Rue de Lausanne 78, 1202 Geneva, Switzerland. yolanda.mueller@freesurf.chIssue Date
2008-01
Metadata
Show full item recordAbstract
Between September 2003 and April 2004, the supply of antimonial drugs to Amudat Hospital, in north-eastern Uganda, was interrupted and all cases of visceral leishmaniasis presenting at the hospital could only be treated with amphotericin B deoxycholate (AmB). This allowed the safety and effectiveness of the AmB to be evaluated, in comparison with an historical cohort of patients treated, at the same hospital, with meglumine antimoniate (Sb(V)). Demographic and clinical data were collected before and after treatment. Adverse effects were recorded passively in all the subjects, and actively, using a standardized questionnaire, in a sub-group of the patients given AmB. The in hospital case-fatality 'rates' were 4.8% [95% confidence interval (CI) = 2.4%-8.8%] among the 210 patients treated with AmB and 3.7% (CI = 1.4%-7.9%) among the 161 patients treated with Sb(V) (P>0.20). Adverse effects requiring treatment interruption were rare in both cohorts. Treatment failures (i.e. non-responses or relapses) were observed in 2.9% (CI = 1.2%-6.4%) of the patients treated with AmB and 1.2% (CI = 0.1%-4.4%) of the patients treated with Sb(V) (P>0.20). For the treatment of visceral leishmaniasis in Uganda, AmB therefore had a similar effectiveness and safety profile to that of meglumine antimoniate.Publisher
Maney PublishingPubMed ID
18186974Additional Links
http://www.maney.co.uk/journals/atmpLanguage
enISSN
0003-4983ae974a485f413a2113503eed53cd6c53
10.1179/136485908X252142
Scopus Count
Collections
Related articles
- Historical series of patients with visceral leishmaniasis treated with meglumine antimoniate in a hospital for tropical diseases, Maceió-AL, Brazil.
- Authors: Silveira LJ, Rocha TJ, Ribeiro SA, Pedrosa CM
- Issue date: 2015 Jan-Feb
- Efficacy and safety of amphotericin B deoxycholate versus N-methylglucamine antimoniate in pediatric visceral leishmaniasis: an open-label, randomized, and controlled pilot trial in Brazil.
- Authors: Borges MM, Pranchevicius MC, Noronha EF, Romero GA, Carranza-Tamayo CO
- Issue date: 2017 Jan-Feb
- Pediatric visceral leishmaniasis in Western Sicily, Italy: a retrospective analysis of 111 cases.
- Authors: Cascio A, Colomba C, Antinori S, Orobello M, Paterson D, Titone L
- Issue date: 2002 Apr
- [Change in human visceral leishmaniasis treatment in Italy: retrospective study of 630 patients].
- Authors: Gradoni L, Gramiccia M, Scalone A
- Issue date: 2004 Jun
- Efficacy and safety of available treatments for visceral leishmaniasis in Brazil: A multicenter, randomized, open label trial.
- Authors: Romero GAS, Costa DL, Costa CHN, de Almeida RP, de Melo EV, de Carvalho SFG, Rabello A, de Carvalho AL, Sousa AQ, Leite RD, Lima SS, Amaral TA, Alves FP, Rode J, Collaborative LVBrasil Group.
- Issue date: 2017 Jun