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    Apr 11, 2021
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    Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.

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    Authors
    Graupner, J
    Göbels, K
    Grobusch, M P
    Lund, A
    Richter, J
    Häussinger, D
    Affiliation
    Medecins sans Frontières (MSF), Max Euweplein 40, 1001, EA, Amsterdam, The Netherlands.
    Issue Date
    2005-06
    
    Metadata
    Show full item record
    Journal
    Parasitology Research
    Abstract
    Falciparum Malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem. Therefore, the parasitological and haematological response to treatment with amodiaquine was studied in children under 5 years during a 14-day follow-up. Of 105 children who accomplished the study (out of 114 who were enrolled), 95.3% were parasite-negative on thick blood film on day 7, which decreased to 89.5% on day 14. The haemoglobin levels increased on average by 1.3% on day 14 (+/-1.9) and more pronounced in children with anaemia<10 g/dl on enrollment. The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine.
    URI
    http://hdl.handle.net/10144/23763
    DOI
    10.1007/s00436-005-1325-7
    PubMed ID
    15864651
    Language
    en
    ISSN
    0932-0113
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00436-005-1325-7
    Scopus Count
    Collections
    Malaria

    entitlement

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