Browsing MSF Research Protocols by Authors
Field evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patientsGupta, Ekta; Carnimeo, Valentina; Samukcham, Inao; Loarec, Anne; Mahajan, Supriya; Choudhary, Manish; Bastard, Mathieu; Maman, David; Page, Anne Laure; MSF-OCA (2018-07)P R O T O C O L S U M M A R Y Title: Field evaluation of the performance of HCV Serological Rapid Diagnostic Tests among HCV/HIV co-infected patients. Aim: To evaluate the performance of serological HCV Rapid Diagnostic Tests (RDTs) to identify tests adapted to resource-limited settings, reliable for HIV-infected patients. Study design: Prospective evaluation of the performance of serological RDTs for HCV screening. Primary objective: o To evaluate the performance of serological HCV RDTs under field conditions using as reference standard a combination of enzyme immunoassay (EIA) and recombinant immunoblot assay (RIBA) for the detection of antibodies anti-HCV in HIV infected patients. Secondary objectives: o To describe the accuracy (sensitivity, specificity) of the RDTs as screening tests o To describe the performance of the RDTs according to the HCV genotype and HCV VL o To describe the performance of the RDTs according to the CD4 counts and HIV VL o To describe the performance of the RDTs in presence of HBV co-infection (presence of antigen anti-HBs (HBsAg)) o To describe the operational characteristics of the tests including ease of use, technical complexity and inter-reader variability. o To evaluate predictive values of each HCV RDT based on the prevalence of the testing center.
Research Protocol - Evaluation of the Nova StatSensor Xpress Creatinine Point-Of-Care Handheld AnalyzerKosack, Cara Simone; de Kieviet, Wim; Bayrak, Kubra; Milovic, Anastacija; Page, Anne Laure; MSF Amsterdam; Department of Clinical Chemistry, Sint Lucas Andreas Ziekenhuis, Amsterdam, Netherlands; Epicentre, Paris, France (2015-04-17)To evaluate the precision and accuracy of the Nova StatSensor® XpressTM Creatinine when compared to the reference method (Ortho Vitros)) at Sint Lucas Andreas Ziekenhuis (SLAZ), Amsterdam, the Netherlands.