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    Jan 19, 2021
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    Adherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysis

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    Authors
    Chacko, Liza
    Ford, Nathan
    Sbaiti, Mariam
    Siddiqui, Ruby
    Affiliation
    Imperial College London, St Mary's Hospital, London, UK; Médecins Sans Frontières, Doctors without Borders (MSF-UK), London, UK; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
    Issue Date
    2012-02-13
    
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    Journal
    Sexually Transmitted Infections
    Abstract
    ObjectiveTo assess adherence to post-exposure prophylaxis (PEP) for the prevention of HIV infection in victims of sexual assault.MethodsThe authors carried out a systematic review, random effects meta-analysis and meta-regression of studies reporting adherence to PEP among victims of sexual violence. Seven electronic databases were searched. Our primary outcome was adherence; secondary outcomes included defaulting, refusal and side effects.Results2159 titles were screened, and 24 studies matching the inclusion criteria were taken through to analysis. The overall proportion of patients adhering to PEP (23 cohort studies, 2166 patients) was 40.3% (95% CI 32.5% to 48.1%), and the overall proportion of patients defaulting from care (18 cohorts, 1972 patients) was 41.2% (95% CI 31.1% to 51.4%). Adherence appeared to be higher in developing countries compared with developed countries.ConclusionsAdherence to PEP is poor in all settings. Interventions are needed to support adherence.
    Publisher
    BMJ Publishing Group
    URI
    http://hdl.handle.net/10144/245351
    DOI
    10.1136/sextrans-2011-050371
    PubMed ID
    22332148
    Additional Links
    http://sti.bmj.com/content/early/2012/02/12/sextrans-2011-050371.short?g=w_sti_ahead_tab
    Type
    Article
    Language
    en
    ISSN
    1472-3263
    ae974a485f413a2113503eed53cd6c53
    10.1136/sextrans-2011-050371
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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