Adherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysis
Affiliation
Imperial College London, St Mary's Hospital, London, UK; Médecins Sans Frontières, Doctors without Borders (MSF-UK), London, UK; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South AfricaIssue Date
2012-02-13
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Sexually Transmitted InfectionsAbstract
ObjectiveTo assess adherence to post-exposure prophylaxis (PEP) for the prevention of HIV infection in victims of sexual assault.MethodsThe authors carried out a systematic review, random effects meta-analysis and meta-regression of studies reporting adherence to PEP among victims of sexual violence. Seven electronic databases were searched. Our primary outcome was adherence; secondary outcomes included defaulting, refusal and side effects.Results2159 titles were screened, and 24 studies matching the inclusion criteria were taken through to analysis. The overall proportion of patients adhering to PEP (23 cohort studies, 2166 patients) was 40.3% (95% CI 32.5% to 48.1%), and the overall proportion of patients defaulting from care (18 cohorts, 1972 patients) was 41.2% (95% CI 31.1% to 51.4%). Adherence appeared to be higher in developing countries compared with developed countries.ConclusionsAdherence to PEP is poor in all settings. Interventions are needed to support adherence.Publisher
BMJ Publishing GroupPubMed ID
22332148Additional Links
http://sti.bmj.com/content/early/2012/02/12/sextrans-2011-050371.short?g=w_sti_ahead_tabType
ArticleLanguage
enISSN
1472-3263ae974a485f413a2113503eed53cd6c53
10.1136/sextrans-2011-050371
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