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dc.contributor.authorChacko, Liza
dc.contributor.authorFord, Nathan
dc.contributor.authorSbaiti, Mariam
dc.contributor.authorSiddiqui, Ruby
dc.date.accessioned2012-09-20T19:10:44Z
dc.date.available2012-09-20T19:10:44Z
dc.date.issued2012-02-13
dc.identifier.citationSex Trans Infect 2012; Published ahead of printen_GB
dc.identifier.issn1472-3263
dc.identifier.pmid22332148
dc.identifier.doi10.1136/sextrans-2011-050371
dc.identifier.urihttp://hdl.handle.net/10144/245351
dc.description.abstractObjectiveTo assess adherence to post-exposure prophylaxis (PEP) for the prevention of HIV infection in victims of sexual assault.MethodsThe authors carried out a systematic review, random effects meta-analysis and meta-regression of studies reporting adherence to PEP among victims of sexual violence. Seven electronic databases were searched. Our primary outcome was adherence; secondary outcomes included defaulting, refusal and side effects.Results2159 titles were screened, and 24 studies matching the inclusion criteria were taken through to analysis. The overall proportion of patients adhering to PEP (23 cohort studies, 2166 patients) was 40.3% (95% CI 32.5% to 48.1%), and the overall proportion of patients defaulting from care (18 cohorts, 1972 patients) was 41.2% (95% CI 31.1% to 51.4%). Adherence appeared to be higher in developing countries compared with developed countries.ConclusionsAdherence to PEP is poor in all settings. Interventions are needed to support adherence.
dc.languageENG
dc.language.isoenen
dc.publisherBMJ Publishing Groupen_GB
dc.relation.urlhttp://sti.bmj.com/content/early/2012/02/12/sextrans-2011-050371.short?g=w_sti_ahead_taben_GB
dc.rightsPublished by BMJ Publishing Group Archived on this site with the kind permission of BMJ Journalsen_GB
dc.subject.meshAcquired Immunodeficiency Syndromeen_GB
dc.titleAdherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysisen
dc.typeArticleen
dc.contributor.departmentImperial College London, St Mary's Hospital, London, UK; Médecins Sans Frontières, Doctors without Borders (MSF-UK), London, UK; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africaen_GB
dc.identifier.journalSexually Transmitted Infectionsen_GB
refterms.dateFOA2019-03-04T09:59:30Z
html.description.abstractObjectiveTo assess adherence to post-exposure prophylaxis (PEP) for the prevention of HIV infection in victims of sexual assault.MethodsThe authors carried out a systematic review, random effects meta-analysis and meta-regression of studies reporting adherence to PEP among victims of sexual violence. Seven electronic databases were searched. Our primary outcome was adherence; secondary outcomes included defaulting, refusal and side effects.Results2159 titles were screened, and 24 studies matching the inclusion criteria were taken through to analysis. The overall proportion of patients adhering to PEP (23 cohort studies, 2166 patients) was 40.3% (95% CI 32.5% to 48.1%), and the overall proportion of patients defaulting from care (18 cohorts, 1972 patients) was 41.2% (95% CI 31.1% to 51.4%). Adherence appeared to be higher in developing countries compared with developed countries.ConclusionsAdherence to PEP is poor in all settings. Interventions are needed to support adherence.


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