TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs.
dc.contributor.author | Kosack, C S | |
dc.contributor.author | Page, A-L | |
dc.contributor.author | Van Hulsteijn, L T | |
dc.contributor.author | Lentjes, E G W M | |
dc.date.accessioned | 2012-10-24T22:52:44Z | |
dc.date.available | 2012-10-24T22:52:44Z | |
dc.date.issued | 2012-03 | |
dc.identifier.citation | PLoS One 2012; 7 (3):e33704. | en_GB |
dc.identifier.issn | 1932-6203 | |
dc.identifier.pmid | 22442713 | |
dc.identifier.doi | 10.1371/journal.pone.0033704 | |
dc.identifier.uri | http://hdl.handle.net/10144/250152 | |
dc.description.abstract | Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed. | |
dc.language.iso | en | en |
dc.relation.url | http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0033704&representation=PDF | en_GB |
dc.rights | Published by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permission | en_GB |
dc.subject | tuberculosis | en_GB |
dc.subject.mesh | Antitubercular Agents | en_GB |
dc.subject.mesh | Diagnosis, Differential | en_GB |
dc.subject.mesh | Female | en_GB |
dc.subject.mesh | Hormone Replacement Therapy | en_GB |
dc.subject.mesh | Humans | en_GB |
dc.subject.mesh | Hypothyroidism | en_GB |
dc.subject.mesh | Male | en_GB |
dc.subject.mesh | Sensitivity and Specificity | en_GB |
dc.subject.mesh | Thyrotropin | en_GB |
dc.subject.mesh | Thyroxine | en_GB |
dc.title | TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs. | en |
dc.type | Article | en |
dc.contributor.department | Medecins sans Frontieres, Amsterdam, The Netherlands; Epicentre, Paris, France; Leiden University Medical Center, Leiden, The Netherlands; University Medical Center Utrecht, Utrecht, The Netherlands. | en_GB |
dc.identifier.journal | PloS One | en_GB |
refterms.dateFOA | 2019-03-04T10:01:32Z | |
html.description.abstract | Thyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed. |