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TSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs.

dc.contributor.authorKosack, C S
dc.contributor.authorPage, A-L
dc.contributor.authorVan Hulsteijn, L T
dc.contributor.authorLentjes, E G W M
dc.date.accessioned2012-10-24T22:52:44Z
dc.date.available2012-10-24T22:52:44Z
dc.date.issued2012-03
dc.identifier.citationPLoS One 2012; 7 (3):e33704.en_GB
dc.identifier.issn1932-6203
dc.identifier.pmid22442713
dc.identifier.doi10.1371/journal.pone.0033704
dc.identifier.urihttp://hdl.handle.net/10144/250152
dc.description.abstractThyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed.
dc.language.isoenen
dc.relation.urlhttp://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0033704&representation=PDFen_GB
dc.rightsPublished by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permissionen_GB
dc.subjecttuberculosisen_GB
dc.subject.meshAntitubercular Agentsen_GB
dc.subject.meshDiagnosis, Differentialen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHormone Replacement Therapyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypothyroidismen_GB
dc.subject.meshMaleen_GB
dc.subject.meshSensitivity and Specificityen_GB
dc.subject.meshThyrotropinen_GB
dc.subject.meshThyroxineen_GB
dc.titleTSH-CHECK-1 test: diagnostic accuracy and potential application to initiating treatment for hypothyroidism in patients on anti-tuberculosis drugs.en
dc.typeArticleen
dc.contributor.departmentMedecins sans Frontieres, Amsterdam, The Netherlands; Epicentre, Paris, France; Leiden University Medical Center, Leiden, The Netherlands; University Medical Center Utrecht, Utrecht, The Netherlands.en_GB
dc.identifier.journalPloS Oneen_GB
refterms.dateFOA2019-03-04T10:01:32Z
html.description.abstractThyroid-stimulating hormone (TSH) promotes expression of thyroid hormones which are essential for metabolism, growth, and development. Second-line drugs to treat tuberculosis (TB) can cause hypothyroidism by suppressing thyroid hormone synthesis. Therefore, TSH levels are routinely measured in TB patients receiving second-line drugs, and thyroxin treatment is initiated where indicated. However, standard TSH tests are technically demanding for many low-resource settings where TB is prevalent; a simple and inexpensive test is urgently needed.


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