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    Jan 16, 2021
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    Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis

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    Ford Safety of efavirenz in the ...
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    Authors
    Ford, Nathan
    Calmy, Alexandra
    Mofenson, Lynne
    Affiliation
    Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa; Médecins Sans Frontières, Geneva, Switzerland; Geneva University Hospital, HIV Unit, Service of Infectious Diseases, Geneva, Switzerland; Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Issue Date
    2011-11-28
    
    Metadata
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    Journal
    AIDS (London, England)
    Abstract
    Evidence of the risk of birth defects with efavirenz use is limited. We updated a meta-analysis of birth defects in infants with first trimester efavirenz exposure up to July 2011. In 21 studies, there were 39 defects among live births in 1437 women receiving first trimester efavirenz [2.0%, 95% confidence interval (CI) 0.82-3.18]. The relative risk of defects comparing women on efavirenz-based (1290 live births) and nonefavirenz-based regimens (8122 live births) was 0.85 (95% CI 0.61-1.20). One neural tube defect was observed (myelomeningocele), giving an incidence of 0.07% (95% CI 0.002-0.39).
    Publisher
    Lippincott Williams & Wilkins
    URI
    http://hdl.handle.net/10144/255366
    DOI
    10.1097/QAD.0b013e32834cdb71
    PubMed ID
    21918421
    Additional Links
    http://journals.lww.com/aidsonline/Abstract/2011/11280/Safety_of_efavirenz_in_the_first_trimester_of.13.aspx
    Type
    Article
    Language
    en
    Description
    Article approval pending
    ISSN
    1473-5571
    ae974a485f413a2113503eed53cd6c53
    10.1097/QAD.0b013e32834cdb71
    Scopus Count
    Collections
    HIV/AIDS

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