Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa
AuthorsLawn, Stephen D
AffiliationThe Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa; School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Medecins Sans Frontieres, Cape Town, South Africa; Division of International and Environmental Health, Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland
MetadataShow full item record
AbstractWe studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.
PublisherLippincott Williams & Wilkins
DescriptionArticle approval pending
- Delays in starting antiretroviral therapy in patients with HIV-associated tuberculosis accessing non-integrated clinical services in a South African township.
- Authors: Lawn SD, Campbell L, Kaplan R, Little F, Morrow C, Wood R, IeDEA-Southern Africa.
- Issue date: 2011 Sep 30
- Impact of ART on TB case fatality stratified by CD4 count for HIV-positive TB patients in Cape Town, South Africa (2009-2011).
- Authors: Kaplan R, Caldwell J, Middelkoop K, Bekker LG, Wood R
- Issue date: 2014 Aug 15
- Time to initiation of antiretroviral therapy in HIV-infected patients diagnosed with an opportunistic disease: a cohort study.
- Authors: Deconinck L, Yazdanpanah Y, Gilson RJ, Melliez H, Viget N, Joly V, Sabin CA
- Issue date: 2015 Apr
- Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa.
- Authors: Schomaker M, Egger M, Maskew M, Garone D, Prozesky H, Hoffmann CJ, Boulle A, Fenner L, IeDEA Southern Africa.
- Issue date: 2013 May 1
- Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa.
- Authors: Lawn SD, Myer L, Bekker LG, Wood R
- Issue date: 2007 Jan 30