Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa
Authors
Lawn, Stephen DCampbell, Lucy
Kaplan, Richard
Boulle, Andrew
Cornell, Morna
Kerschberger, Bernhard
Morrow, Carl
Little, Francesca
Egger, Matthias
Wood, Robin
Affiliation
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa; School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Medecins Sans Frontieres, Cape Town, South Africa; Division of International and Environmental Health, Institute of Social and Preventive Medicine (ISPM), University of Bern, SwitzerlandIssue Date
2011-06-01
Metadata
Show full item recordAbstract
We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.Publisher
Lippincott Williams & WilkinsPubMed ID
21436714Additional Links
http://journals.lww.com/jaids/Abstract/2011/06010/Time_to_Initiation_of_Antiretroviral_Therapy_Among.7.aspxType
ArticleLanguage
enDescription
Article approval pendingISSN
1944-7884ae974a485f413a2113503eed53cd6c53
10.1097/QAI.0b013e3182199ee9
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