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    Apr 14, 2021
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    In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness

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    Authors
    Schmid, C
    Kuemmerle, A
    Blum, J
    Ghabri, S
    Kande, V
    Mutombo, W
    Ilunga, M
    Lumpungu, I
    Mutanda, S
    Nganzobo, P
    Tete, D
    Mubwa, N
    Kisala, M
    Blesson, S
    Mordt, O V
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    Affiliation
    Department of Medicines Research, Swiss Tropical and Public Health Institute, Basel, Switzerland.
    Issue Date
    2012-11-29
    
    Metadata
    Show full item record
    Journal
    PLoS Neglected Tropical Diseases
    Abstract
    Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and insufficiently effective in certain areas (melarsoprol). Recently, nifurtimox-eflornithine combination therapy (NECT) demonstrated good safety and efficacy in a randomised controlled trial (RCT) and was added to the World Health Organisation (WHO) essential medicines list (EML). Documentation of its safety profile in field conditions will support its wider use.
    URI
    http://hdl.handle.net/10144/272002
    DOI
    10.1371/journal.pntd.0001920
    PubMed ID
    23209861
    Language
    en
    ISSN
    1935-2735
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pntd.0001920
    Scopus Count
    Collections
    Trypanosomiasis/Sleeping Sickness

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