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    Jan 20, 2021
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    Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria

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    Authors
    Van Malderen, Carine
    Van Geertruyden, Jean-Pierre
    Machevo, Sonia
    González, Raquel
    Bassat, Quique
    Talisuna, Ambrose
    Yeka, Adoke
    Nabasumba, Carolyn
    Piola, Patrice
    Daniel, Atwine
    Turyakira, Eleanor
    Forret, Pascale
    Van Overmeir, Chantal
    van Loen, Harry
    Robert, Annie
    D' Alessandro, Umberto
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    Affiliation
    Faculté de pharmacie et des sciences biomédicales, Université catholique de Louvain, Brussels, Belgium. carine.vanmalderen@uclouvain.be
    Issue Date
    2012-04-30
    
    Metadata
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    Journal
    Malaria Journal
    Abstract
    Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped because of safety concerns secondary to its associated risk of haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The objective of the study was to assess whether CDA treatment and G6PD deficiency are risk factors for a post-treatment haemoglobin drop in African children<5 years of age with uncomplicated malaria.
    URI
    http://hdl.handle.net/10144/272004
    DOI
    10.1186/1475-2875-11-139
    PubMed ID
    22546009
    Language
    en
    ISSN
    1475-2875
    ae974a485f413a2113503eed53cd6c53
    10.1186/1475-2875-11-139
    Scopus Count
    Collections
    Malaria

    entitlement

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