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    Jan 17, 2021
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    Artemether-Lumefantrine to treat Malaria in pregnancy is associated with reduced placental Haemozoin deposition compared to Quinine in a randomized controlled trial

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    Authors
    Muehlenbachs, Atis
    Nabasumba, Carolyn
    McGready, Rose
    Turyakira, Eleanor
    Tumwebaze, Benon
    Dhorda, Mehul
    Nyehangane, Dan
    Nalusaji, Aisha
    Nosten, Franois
    Guerin, Philippe J
    Piola, Patrice
    Show allShow less
    Affiliation
    Department of Pathology, University of Washington, Box 357470, 1959 NE Pacific Street, Seattle, WA, USA. amuehlen@u.washington.edu
    Issue Date
    2012-05-03
    
    Metadata
    Show full item record
    Journal
    Malaria Journal
    Abstract
    Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda demonstrated that artemether-lumefantrine (AL) is not inferior to quinine to treat uncomplicated malaria in pregnancy. Haemozoin can persist in the placenta following clearance of parasites, however there is no data whether ACT can influence the amount of haemozoin or the dynamics of haemozoin clearance.
    URI
    http://hdl.handle.net/10144/272006
    DOI
    10.1186/1475-2875-11-150
    PubMed ID
    22554092
    Language
    en
    ISSN
    1475-2875
    ae974a485f413a2113503eed53cd6c53
    10.1186/1475-2875-11-150
    Scopus Count
    Collections
    Malaria

    entitlement

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