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    Jan 17, 2021
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    Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marche Hospital, Bunia, Democratic Republic of Congo

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    Mueller- Effectiveness of blood ...
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    Authors
    Mueller, Y
    Bastard, M
    Ehounou, G
    Itama, J
    Quéré, M
    de la Tour, R
    Vala, L
    Etard, J-F
    Bottineau, M-C
    Affiliation
    Epicentre, Paris, France  Médecins Sans Frontières, Geneva, Switzerland  National Program for Blood Transfusion, Bunia, Democratic Republic of the Congo.
    Issue Date
    2012-10-11
    
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    Journal
    Tropical Medicine & International Health
    Abstract
    Objective  To assess the effectiveness of blood transfusions in a hospital of north-eastern Democratic Republic of the Congo. Methods  Prospective study of children admitted for severe anaemia. During admission, data were collected on clinical condition and haemoglobin levels, before and after blood transfusion. A linear regression model was built to explore factors associated with haemoglobin level after transfusion. Risk factors for mortality were explored through multivariate logistic regression. Results  Haemoglobin level (Hb) was below 4 g/dl in 35% (230/657), between 4 and 6 g/dl in 58% (348/657) and at least 6 g/dl in another 6% (43/657) of the transfused children. A transfusion of 15 ml/kg of whole blood increased the Hb from 4.4 to 7.8 g/dl. Haemoglobin level after transfusion was associated with baseline Hb, quantity of delivered blood and history of previous transfusions. Overall case-fatality rate was 5.6% (37/657). Risk factors for deaths were co-morbidities such as chest infection, meningitis or malnutrition, Hb ≥ 6 g/dl, impaired consciousness or jugular venous distention on admission, and provenance. Conclusion  Transfusion was a frequent practice, the use of which could clearly have been rationalised. While indications should be restricted, quantities of transfused blood should be adapted to needs.
    URI
    http://hdl.handle.net/10144/279017
    DOI
    10.1111/j.1365-3156.2012.03095.x
    PubMed ID
    23051824
    Language
    en
    ISSN
    1365-3156
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-3156.2012.03095.x
    Scopus Count
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    Paediatrics

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