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dc.contributor.authorRoberts, Teri
dc.contributor.authorBygrave, Helen
dc.contributor.authorFajardo, Emmanuel
dc.contributor.authorFord, Nathan
dc.date.accessioned2013-04-11T22:14:37Z
dc.date.available2013-04-11T22:14:37Z
dc.date.issued2012-10-09
dc.identifier.citationChallenges and opportunities for the implementation of virological testing in resource-limited settings. 2012, 15 (2):17324 J Int AIDS Socen_GB
dc.identifier.issn1758-2652
dc.identifier.pmid23078767
dc.identifier.urihttp://hdl.handle.net/10144/280932
dc.description.abstractThough the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation. Monitoring is important for diagnosing virological failure early on, before the development of drug resistance mutations, and to trigger early adherence interventions. Simple and cost-effective viral load tests that facilitate simplification and decentralization of testing and strategies, such as the use of dried blood spots and pooled sample testing, which further aid simplification, are becoming available. In addition, replacing immunological monitoring with virological monitoring in non-viremic patients in a phased manner will reduce the costs associated with dual immuno-virological monitoring. Going forward, the simplification of testing paired with price reducing strategies that will allow for healthy competition between multiple manufacturers will enable the implementation of viral load testing in resource-poor settings. It is important that future HIV and AIDS treatment guidelines provide clear recommendations for routine virological monitoring and that governments and donors fund the implementation of accurate and operationally proven testing platforms in a comprehensive manner.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of the International AIDS Societyen_GB
dc.subject.meshAnti-HIV Agentsen_GB
dc.subject.meshBlooden_GB
dc.subject.meshDesiccationen_GB
dc.subject.meshDeveloping Countriesen_GB
dc.subject.meshDrug Monitoringen_GB
dc.subject.meshHIVen_GB
dc.subject.meshHIV Infectionsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshSpecimen Handlingen_GB
dc.subject.meshViral Loaden_GB
dc.titleChallenges and Opportunities for the Implementation of Virological Testing in resource-limited settingsen
dc.contributor.departmentMédecins Sans Frontières Access Campaign, Geneva, Switzerland. teri.roberts@geneva.msf.orgen_GB
dc.identifier.journalJournal of the International AIDS Societyen_GB
refterms.dateFOA2019-03-04T10:29:16Z
html.description.abstractThough the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation. Monitoring is important for diagnosing virological failure early on, before the development of drug resistance mutations, and to trigger early adherence interventions. Simple and cost-effective viral load tests that facilitate simplification and decentralization of testing and strategies, such as the use of dried blood spots and pooled sample testing, which further aid simplification, are becoming available. In addition, replacing immunological monitoring with virological monitoring in non-viremic patients in a phased manner will reduce the costs associated with dual immuno-virological monitoring. Going forward, the simplification of testing paired with price reducing strategies that will allow for healthy competition between multiple manufacturers will enable the implementation of viral load testing in resource-poor settings. It is important that future HIV and AIDS treatment guidelines provide clear recommendations for routine virological monitoring and that governments and donors fund the implementation of accurate and operationally proven testing platforms in a comprehensive manner.


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