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    Jan 27, 2021
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    Kashin-Beck disease and iodine deficiency in Tibet.

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    Authors
    Moreno-Reyes, R
    Suetens, C
    Mathieu, F
    Begaux, F
    Zhu, D
    Rivera, M
    Boelaert, M
    Nève, J
    Perlmutter, N
    Vanderpas, J
    Affiliation
    Department of Nuclear Medicine, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.be
    Issue Date
    2001
    
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    Journal
    International Orthopaedics
    Abstract
    We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.
    URI
    http://hdl.handle.net/10144/28678
    PubMed ID
    11482533
    Language
    en
    ISSN
    0341-2695
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