Authors
Moreno-Reyes, RSuetens, C
Mathieu, F
Begaux, F
Zhu, D
Rivera, M
Boelaert, M
Nève, J
Perlmutter, N
Vanderpas, J
Affiliation
Department of Nuclear Medicine, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.beIssue Date
2001
Metadata
Show full item recordJournal
International OrthopaedicsAbstract
We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.PubMed ID
11482533Language
enISSN
0341-2695Collections
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