Show simple item record

dc.contributor.authorGraham, S M
dc.contributor.authorAhmed, T
dc.contributor.authorAmanullah, F
dc.contributor.authorBrowning, R
dc.contributor.authorCardenas, V
dc.contributor.authorCasenghi, M
dc.contributor.authorCuevas, L E
dc.contributor.authorGale, M
dc.contributor.authorGie, R P
dc.contributor.authorGrzemska, M
dc.contributor.authorHandelsman, E
dc.contributor.authorHatherill, M
dc.contributor.authorHesseling, A C
dc.contributor.authorJean-Philippe, P
dc.contributor.authorKampmann, B
dc.contributor.authorKabra, S K
dc.contributor.authorLienhardt, C
dc.contributor.authorLighter-Fisher, J
dc.contributor.authorMadhi, S
dc.contributor.authorMakhene, M
dc.contributor.authorMarais, B J
dc.contributor.authorMcNeeley, D F
dc.contributor.authorMenzies, H
dc.contributor.authorMitchell, C
dc.contributor.authorModi, S
dc.contributor.authorMofenson, L
dc.contributor.authorMusoke, P
dc.contributor.authorNachman, S
dc.contributor.authorPowell, C
dc.contributor.authorRigaud, M
dc.contributor.authorRouzier, V
dc.contributor.authorStarke, J R
dc.contributor.authorSwaminathan, S
dc.contributor.authorWingfield, C
dc.date.accessioned2013-10-16T20:28:51Z
dc.date.available2013-10-16T20:28:51Z
dc.date.issued2012-03-22
dc.identifier.citationEvaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel. 2012, 205 Suppl 2:S199-208 J. Infect. Dis.en_GB
dc.identifier.issn1537-6613
dc.identifier.pmid22448023
dc.identifier.doi10.1093/infdis/jis008
dc.identifier.urihttp://hdl.handle.net/10144/303525
dc.descriptionTo access this article, click on "Additional Links"en_GB
dc.description.abstractThere is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis.
dc.language.isoenen
dc.publisherOxford University Pressen_GB
dc.relation.urlhttp://jid.oxfordjournals.org//cgi/reprint/205/suppl_2/S199?ijkey=RSRXmixi7RdwY&keytype=ref&siteid=jinfdisen_GB
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2012 by the Infectious Diseases Society of America, [url] and Oxford University Pressen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAge Factorsen_GB
dc.subject.meshAntitubercular Agentsen_GB
dc.subject.meshBacteriological Techniquesen_GB
dc.subject.meshChilden_GB
dc.subject.meshChild, Preschoolen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfanten_GB
dc.subject.meshTuberculosis, Pulmonaryen_GB
dc.titleEvaluation of Tuberculosis Diagnostics in Children: 1. Proposed clinical case definitions for classification of Intrathoracic Tuberculosis Disease. Consensus from an expert panelen
dc.contributor.departmentCentre for International Child Health, University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia. steve.graham@rch.org.auen_GB
dc.identifier.journalJournal of Infectious Diseasesen_GB
html.description.abstractThere is a critical need for improved diagnosis of tuberculosis in children, particularly in young children with intrathoracic disease as this represents the most common type of tuberculosis in children and the greatest diagnostic challenge. There is also a need for standardized clinical case definitions for the evaluation of diagnostics in prospective clinical research studies that include children in whom tuberculosis is suspected but not confirmed by culture of Mycobacterium tuberculosis. A panel representing a wide range of expertise and child tuberculosis research experience aimed to develop standardized clinical research case definitions for intrathoracic tuberculosis in children to enable harmonized evaluation of new tuberculosis diagnostic technologies in pediatric populations. Draft definitions and statements were proposed and circulated widely for feedback. An expert panel then considered each of the proposed definitions and statements relating to clinical definitions. Formal group consensus rules were established and consensus was reached for each statement. The definitions presented in this article are intended for use in clinical research to evaluate diagnostic assays and not for individual patient diagnosis or treatment decisions. A complementary article addresses methodological issues to consider for research of diagnostics in children with suspected tuberculosis.


This item appears in the following Collection(s)

Show simple item record