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    Apr 17, 2021
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    Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach

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    Klarkowski et al-2013-Variation ...
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    Authors
    Klarkowski, Derryck
    Glass, Kathryn
    O'Brien, Daniel
    Lokuge, Kamalini
    Piriou, Erwan
    Shanks, Leslie
    Affiliation
    Médecins sans Frontières, Operational Centre Amsterdam, Amsterdam, The Netherlands
    Issue Date
    2013-11
    
    Metadata
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    Journal
    PloS ONE
    Abstract
    Recent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or three rapid diagnostic tests (RDTs) combined in an algorithm and assume a population is serologically stable over time. Yet RDTs are prone to cross reactivity which can lead to false positive or discordant results. This paper uses discordancy data from Médecins Sans Frontières (MSF) programmes to test the hypothesis that the specificity of RDTs change over place and time.
    Publisher
    Public Library of Science
    URI
    http://hdl.handle.net/10144/311607
    DOI
    10.1371/journal.pone.0081656
    PubMed ID
    24282615
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0081656
    Scopus Count
    Collections
    HIV/AIDS

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