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    Mar 02, 2021
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    Clinical Epidemiology, Diagnosis and Treatment of Visceral Leishmaniasis in the Pokot Endemic Area of Uganda and Kenya

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    Name:
    Mueller et al-2013-Clinical ...
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    Authors
    Mueller, Yolanda K
    Kolaczinski, Jan H
    Koech, Timothy
    Lokwang, Peter
    Riongoita, Mark
    Velilla, Elena
    Brooker, Simon J
    Chappuis, François
    Affiliation
    Epicentre, Paris, France; Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom; Médecins Sans Frontières, Operational Centre, Geneva, Switzerland; Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
    Issue Date
    2013-11-11
    
    Metadata
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    Journal
    The American Journal of Tropical Medicine and Hygiene
    Abstract
    Between 2000 and 2010, Médecins Sans Frontières diagnosed and treated 4,831 patients with visceral leishmaniasis (VL) in the Pokot region straddling the border between Uganda and Kenya. A retrospective analysis of routinely collected clinical data showed no marked seasonal or annual fluctuations. Males between 5 and 14 years of age were the most affected group. Marked splenomegaly and anemia were striking features. An Rk39 antigen-based rapid diagnostic test was evaluated and found sufficiently accurate to replace the direct agglutination test and spleen aspiration as the first-line diagnostic procedure. The case-fatality rate with sodium stibogluconate as first-line treatment was low. The VL relapses were rare and often diagnosed more than 6 months post-treatment. Post-kala-azar dermal leishmaniasis was rare but likely to be underdiagnosed. The epidemiological and clinical features of VL in the Pokot area differed markedly from VL in Sudan, the main endemic focus in Africa.
    URI
    http://hdl.handle.net/10144/311672
    DOI
    10.4269/ajtmh.13-0150
    PubMed ID
    24218406
    Additional Links
    http://www.ajtmh.org
    Language
    en
    ISSN
    1476-1645
    ae974a485f413a2113503eed53cd6c53
    10.4269/ajtmh.13-0150
    Scopus Count
    Collections
    Leishmaniasis/Kala Azar

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