Kala-azar outbreak in Libo Kemkem, Ethiopia: epidemiologic and parasitologic assessment.
AffiliationDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, 20 Avenue Appia, CH-1211 Geneva, Switzerland. firstname.lastname@example.org
MetadataShow full item record
AbstractIn May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemkem, Ethiopia. In October 2005, a rapid assessment was conducted using data from 492 patients with VL treated in the district health center and a household survey of 584 residents of four villages. One subdistrict accounted for 71% of early cases, but the incidence and number of affected subdistricts increased progressively throughout 2004-2005. In household-based data, we identified 9 treated VL cases, 12 current untreated cases, and 19 deaths attributable to VL (cumulative incidence, 7%). Thirty percent of participants were leishmanin skin test positive (men, 34%; women, 26%; P = 0.06). VL was more common in men than women (9.7% versus 4.5%, P < 0.05), possibly reflecting male outdoor sleeping habits. Molecular typing in splenic aspirates showed L. infantum (six) and L. donovani (one). Local transmission resulted from multiple introductions, is now well established, and will be difficult to eradicate.
DescriptionThis study as conducted in collaboration with MSF Greece and Spain.
- Low prevalence of Leishmania infection in post-epidemic areas of Libo Kemkem, Ethiopia.
- Authors: Sordo L, Gadisa E, Custodio E, Cruz I, Simón F, Abraham Z, Moreno J, Aseffa A, Tsegaye H, Nieto J, Chicharro C, Cañavate C
- Issue date: 2012 Jun
- Multilocus microsatellite typing revealed high genetic variability of Leishmania donovani strains isolated during and after a Kala-azar epidemic in Libo Kemkem district, northwest Ethiopia.
- Authors: Gelanew T, Cruz I, Kuhls K, Alvar J, Cañavate C, Hailu A, Schönian G
- Issue date: 2011 Jun
- Usefulness of the rK39-immunochromatographic test, direct agglutination test, and leishmanin skin test for detecting asymptomatic Leishmania infection in children in a new visceral leishmaniasis focus in Amhara State, Ethiopia.
- Authors: Gadisa E, Custodio E, Cañavate C, Sordo L, Abebe Z, Nieto J, Chicharro C, Aseffa A, Yamuah L, Engers H, Moreno J, Cruz I
- Issue date: 2012 May
- Use of Leishmania major derived leishmanin for skin test surveys of visceral leishmaniasis in Ethiopia.
- Authors: Hailu A, Berhe N, Ali A, Gemetchu T
- Issue date: 1997 Jan
- Natural history of a visceral leishmaniasis outbreak in highland Ethiopia.
- Authors: Herrero M, Orfanos G, Argaw D, Mulugeta A, Aparicio P, Parreño F, Bernal O, Rubens D, Pedraza J, Lima MA, Flevaud L, Palma PP, Bashaye S, Alvar J, Bern C
- Issue date: 2009 Sep