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    Mar 03, 2021
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    Causes of false-positive HIV rapid diagnostic test results

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    Klarkowski 2014-Causes of false ...
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    Authors
    Klarkowski, Derryck
    O'Brien, Daniel P
    Shanks, Leslie
    Singh, Kasha P
    Issue Date
    2014-01
    
    Metadata
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    Journal
    Expert Review of Anti-Infective Therapy
    Abstract
    HIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same cause for false positivity, a false-positive diagnosis may result in devastating consequences. In resource-limited settings, the lack of routine confirmatory testing, compounded by incorrect interpretation of weak positive test lines and use of tie-breaker algorithms, can leave a false-positive diagnosis undetected. We propose that heightened CD5+ and early B-lymphocyte response polyclonal cross-reactivity are a major cause of HIV false positivity in certain settings; thus, test performance may vary significantly in different geographical areas and populations. There is an urgent need for policy makers to recognize that HIV rapid diagnostic tests are screening tests and mandate confirmatory testing before reporting an HIV-positive result. In addition, weak positive results should not be recognized as valid except in the screening of blood donors.
    Publisher
    Informa Healthcare
    URI
    http://hdl.handle.net/10144/316420
    DOI
    10.1586/14787210.2014.866516
    PubMed ID
    24404993
    Language
    en
    ISSN
    1744-8336
    ae974a485f413a2113503eed53cd6c53
    10.1586/14787210.2014.866516
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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