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dc.contributor.authorKlarkowski, Derryck
dc.contributor.authorO'Brien, Daniel P
dc.contributor.authorShanks, Leslie
dc.contributor.authorSingh, Kasha P
dc.date.accessioned2014-05-01T17:49:12Z
dc.date.available2014-05-01T17:49:12Z
dc.date.issued2014-01
dc.identifier.citationCauses of false-positive HIV rapid diagnostic test results. 2014, 12 (1):49-62 Expert Rev Anti Infect Theren_GB
dc.identifier.issn1744-8336
dc.identifier.pmid24404993
dc.identifier.doi10.1586/14787210.2014.866516
dc.identifier.urihttp://hdl.handle.net/10144/316420
dc.description.abstractHIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same cause for false positivity, a false-positive diagnosis may result in devastating consequences. In resource-limited settings, the lack of routine confirmatory testing, compounded by incorrect interpretation of weak positive test lines and use of tie-breaker algorithms, can leave a false-positive diagnosis undetected. We propose that heightened CD5+ and early B-lymphocyte response polyclonal cross-reactivity are a major cause of HIV false positivity in certain settings; thus, test performance may vary significantly in different geographical areas and populations. There is an urgent need for policy makers to recognize that HIV rapid diagnostic tests are screening tests and mandate confirmatory testing before reporting an HIV-positive result. In addition, weak positive results should not be recognized as valid except in the screening of blood donors.
dc.language.isoenen
dc.publisherInforma Healthcareen_GB
dc.rightsArchived with thanks to Expert Review of Anti-Infective Therapyen_GB
dc.subjectDiagnosticsen_GB
dc.subjectHIV/AIDSen_GB
dc.titleCauses of false-positive HIV rapid diagnostic test resultsen
dc.identifier.journalExpert Review of Anti-Infective Therapyen_GB
refterms.dateFOA2019-03-04T11:14:12Z
html.description.abstractHIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same cause for false positivity, a false-positive diagnosis may result in devastating consequences. In resource-limited settings, the lack of routine confirmatory testing, compounded by incorrect interpretation of weak positive test lines and use of tie-breaker algorithms, can leave a false-positive diagnosis undetected. We propose that heightened CD5+ and early B-lymphocyte response polyclonal cross-reactivity are a major cause of HIV false positivity in certain settings; thus, test performance may vary significantly in different geographical areas and populations. There is an urgent need for policy makers to recognize that HIV rapid diagnostic tests are screening tests and mandate confirmatory testing before reporting an HIV-positive result. In addition, weak positive results should not be recognized as valid except in the screening of blood donors.


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