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    Jan 17, 2021
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    Visceral Leishmaniasis and HIV Coinfection in East Africa

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    Diro-2014-visceral leishmaniasis ...
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    Authors
    Diro, Ermias
    Lynen, Lutgarde
    Ritmeijer, Koert
    Boelaert, Marleen
    Hailu, Asrat
    van Griensven, Johan
    Issue Date
    2014-06-26
    
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    Journal
    PLoS Neglected Tropical Diseases
    Abstract
    Visceral Leishmaniasis (VL) is an important protozoan opportunistic disease in HIV patients in endemic areas. East Africa is second to the Indian subcontinent in the global VL caseload and first in VL-HIV coinfection rate. Because of the alteration in the disease course, the diagnostic challenges, and the poor treatment responses, VL with HIV coinfection has become a very serious challenge in East Africa today. Field experience with the use of liposomal amphotericin B in combination with miltefosine, followed by secondary prophylaxis and antiretroviral drugs, looks promising. However, this needs to be confirmed through clinical trials. Better diagnostic and follow-up methods for relapse and prediction of relapse should also be looked for. Basic research to understand the immunological interaction of the two infections may ultimately help to improve the management of the coinfection.
    URI
    http://hdl.handle.net/10144/322463
    DOI
    10.1371/journal.pntd.0002869
    PubMed ID
    24968313
    Language
    en
    ISSN
    1935-2735
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pntd.0002869
    Scopus Count
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    Leishmaniasis/Kala Azar

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