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    Mar 04, 2021
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    False-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results.

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    Authors
    Boyles, T H
    Hughes, J
    Cox, V
    Burton, R
    Meintjes, G
    Mendelson, M
    Issue Date
    2014-07
    
    Metadata
    Show full item record
    Journal
    International Journal of Tuberculosis and Lung Disease
    Abstract
    Xpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients.
    URI
    http://hdl.handle.net/10144/322672
    DOI
    10.5588/ijtld.13.0853
    PubMed ID
    24902569
    Language
    en
    ISSN
    1815-7920
    ae974a485f413a2113503eed53cd6c53
    10.5588/ijtld.13.0853
    Scopus Count
    Collections
    TB

    entitlement

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