False-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results.
| dc.contributor.author | Boyles, T H | |
| dc.contributor.author | Hughes, J | |
| dc.contributor.author | Cox, V | |
| dc.contributor.author | Burton, R | |
| dc.contributor.author | Meintjes, G | |
| dc.contributor.author | Mendelson, M | |
| dc.date.accessioned | 2014-07-08T15:47:12Z | |
| dc.date.available | 2014-07-08T15:47:12Z | |
| dc.date.issued | 2014-07 | |
| dc.identifier.citation | False-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results. 2014, 18 (7):876-8 Int. J. Tuberc. Lung Dis. | en_GB |
| dc.identifier.issn | 1815-7920 | |
| dc.identifier.pmid | 24902569 | |
| dc.identifier.doi | 10.5588/ijtld.13.0853 | |
| dc.identifier.uri | http://hdl.handle.net/10144/322672 | |
| dc.description.abstract | Xpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Disease | en_GB |
| dc.title | False-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results. | en |
| dc.identifier.journal | International Journal of Tuberculosis and Lung Disease | en_GB |
| refterms.dateFOA | 2019-03-04T11:20:36Z | |
| html.description.abstract | Xpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients. |
