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dc.contributor.authorBoyles, T H
dc.contributor.authorHughes, J
dc.contributor.authorCox, V
dc.contributor.authorBurton, R
dc.contributor.authorMeintjes, G
dc.contributor.authorMendelson, M
dc.date.accessioned2014-07-08T15:47:12Z
dc.date.available2014-07-08T15:47:12Z
dc.date.issued2014-07
dc.identifier.citationFalse-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results. 2014, 18 (7):876-8 Int. J. Tuberc. Lung Dis.en_GB
dc.identifier.issn1815-7920
dc.identifier.pmid24902569
dc.identifier.doi10.5588/ijtld.13.0853
dc.identifier.urihttp://hdl.handle.net/10144/322672
dc.description.abstractXpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients.
dc.language.isoenen
dc.rightsArchived with thanks to The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Diseaseen_GB
dc.titleFalse-positive Xpert(®) MTB/RIF assays in previously treated patients: need for caution in interpreting results.en
dc.identifier.journalInternational Journal of Tuberculosis and Lung Diseaseen_GB
refterms.dateFOA2019-03-04T11:20:36Z
html.description.abstractXpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients.


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