Show simple item record

dc.contributor.authorNeri, Antonio Jamesen_GB
dc.contributor.authorRoy, Joannieen_GB
dc.contributor.authorJarrett, Jefferyen_GB
dc.contributor.authorPan, Yien_GB
dc.contributor.authorDooyema, Carrieen_GB
dc.contributor.authorCaldwell, Kathleenen_GB
dc.contributor.authorUmar-Tsafe, Nasir Tsafeen_GB
dc.contributor.authorOlubiyo, Ruthen_GB
dc.contributor.authorBrown, Mary Jeanen_GB
dc.date.accessioned2014-07-24T21:43:45Z
dc.date.available2014-07-24T21:43:45Z
dc.date.issued2013-10
dc.identifier.citationAnalysis of a novel field dilution method for testing samples that exceed the analytic range of point-of-care blood lead analyzers. 2014, 24 (5):418-28 Int J Environ Health Resen_GB
dc.identifier.issn1369-1619
dc.identifier.pmid24266724
dc.identifier.doi10.1080/09603123.2013.857390
dc.identifier.urihttp://hdl.handle.net/10144/323778
dc.descriptionTo access this article, click on "Additional Links".en_GB
dc.description.abstractInvestigators developed and evaluated a dilution method for the LeadCare II analyzer (LCII) for blood lead levels >65 μg/dL, the analyzer's maximum reporting value. Venous blood samples from lead-poisoned children were initially analyzed in the field using the dilution method. Split samples were analyzed at the US Centers for Disease Control and Prevention (CDC) laboratory using both the dilution method and inductively coupled plasma-mass spectrometry (ICP-MS). The concordance correlation coefficient of CDC LCII vs. ICP-MS values (N = 211) was 0.976 (95 % confidence interval (CI) 0.970-0.981); of Field LCII vs. ICP-MS (N = 68) was 0.910 (95% CI 0.861-0.942), and CDC LCII vs. Field LCII (N = 53) was 0.721 (95% CI 0.565-0.827). Sixty percent of CDC and 54% of Field LCII values were within ±10% of the ICP-MS value. Results from the dilution method approximated ICP-MS values and were useful for field-based decision-making. Specific recommendations for additional evaluation are provided.
dc.language.isoenen
dc.publisherTaylor and Francis Groupen_GB
dc.relation.urlhttp://www.tandfonline.com/doi/full/10.1080/09603123.2013.857390en_GB
dc.rightsArchived with thanks to the Taylor and Francis Group and International journal of environmental health researchen_GB
dc.titleAnalysis of a novel field dilution method for testing samples that exceed the analytic range of point-of-care blood lead analyzers.en
dc.identifier.journalInternational Journal of Environmental Health Researchen_GB
html.description.abstractInvestigators developed and evaluated a dilution method for the LeadCare II analyzer (LCII) for blood lead levels >65 μg/dL, the analyzer's maximum reporting value. Venous blood samples from lead-poisoned children were initially analyzed in the field using the dilution method. Split samples were analyzed at the US Centers for Disease Control and Prevention (CDC) laboratory using both the dilution method and inductively coupled plasma-mass spectrometry (ICP-MS). The concordance correlation coefficient of CDC LCII vs. ICP-MS values (N = 211) was 0.976 (95 % confidence interval (CI) 0.970-0.981); of Field LCII vs. ICP-MS (N = 68) was 0.910 (95% CI 0.861-0.942), and CDC LCII vs. Field LCII (N = 53) was 0.721 (95% CI 0.565-0.827). Sixty percent of CDC and 54% of Field LCII values were within ±10% of the ICP-MS value. Results from the dilution method approximated ICP-MS values and were useful for field-based decision-making. Specific recommendations for additional evaluation are provided.


This item appears in the following Collection(s)

Show simple item record