Visceral Leishmaniasis and HIV Co-infection in Bihar, India: Long-term Effectiveness and Treatment Outcomes with Liposomal Amphotericin B (AmBisome).
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Burza et al. - 2014 - Visceral ...
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Authors
Burza, SakibMahajan, Raman
Sinha, Prabhat K
van Griensven, Johan
Pandey, Krishna
Lima, María Angeles
Sanz, Marta Gonzalez
Sunyoto, Temmy
Kumar, Sunil
Mitra, Gaurab
Kumar, Ranjeet
Verma, Neena
Das, Pradeep
Issue Date
2014-08-07
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PLoS Neglected Tropical DiseasesAbstract
Visceral Leishmaniasis (VL; also known as kala-azar) is an ultimately fatal disease endemic in the Indian state of Bihar, while HIV/AIDS is an emerging disease in this region. A 2011 observational cohort study conducted in Bihar involving 55 VL/HIV co-infected patients treated with 20-25 mg/kg intravenous liposomal amphotericin B (AmBisome) estimated an 85.5% probability of survival and a 26.5% probability of VL relapse within 2 years. Here we report the long-term field outcomes of a larger cohort of co-infected patients treated with this regimen between 2007 and 2012.Publisher
PLoSPubMed ID
25101665Language
enISSN
1935-2735ae974a485f413a2113503eed53cd6c53
10.1371/journal.pntd.0003053
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