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    Jan 17, 2021
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    Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia.

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    Name:
    Alifrangis et al-2014-Independent ...
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    Authors
    Alifrangis, Michael
    Nag, Sidsel
    Schousboe, Mette L
    Ishengoma, Deus
    Lusingu, John
    Pota, Hirva
    Kavishe, Reginald A
    Pearce, Richard
    Ord, Rosalynn
    Lynch, Caroline
    Dejene, Seyoum
    Cox, Jonathan
    Rwakimari, John
    Minja, Daniel T R
    Lemnge, Martha M
    Roper, Cally
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    Issue Date
    2014-08
    
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    Journal
    Emerging Infectious Diseases
    Abstract
    Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004-2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages.
    URI
    http://hdl.handle.net/10144/325834
    DOI
    10.3201/eid2008.131897
    PubMed ID
    25061906
    Language
    en
    ISSN
    1080-6059
    ae974a485f413a2113503eed53cd6c53
    10.3201/eid2008.131897
    Scopus Count
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    Malaria

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