AffiliationTravel and Migration Medicine Unit, Geneva University Hospital, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. firstname.lastname@example.org
MetadataShow full item record
JournalClinical Microbiology Reviews
AbstractHuman African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense or T. b. rhodesiense remains highly prevalent in several rural areas of sub-Saharan Africa and is lethal if left untreated. Therefore, accurate tools are absolutely required for field diagnosis. For T. b. gambiense HAT, highly sensitive tests are available for serological screening but the sensitivity of parasitological confirmatory tests remains insufficient and needs to be improved. Screening for T. b. rhodesiense infection still relies on clinical features in the absence of serological tests available for field use. Ongoing research is opening perspectives for a new generation of field diagnostics. Also essential for both forms of HAT is accurate determination of the disease stage because of the high toxicity of melarsoprol, the drug most widely used during the neurological stage of the illness. Recent studies have confirmed the high accuracy of raised immunoglobulin M levels in the cerebrospinal fluid for the staging of T. b. gambiense HAT, and a promising simple assay (LATEX/IgM) is being tested in the field. Apart from the urgent need for better tools for the field diagnosis of this neglected disease, improved access to diagnosis and treatment for the population at risk remains the greatest challenge for the coming years.
PublisherThe American Society for Microbiology
- A pilot study demonstrating the identification of Trypanosoma brucei gambiense and T. b. rhodesiense in vectors using a multiplexed high-resolution melt qPCR.
- Authors: Garrod G, Adams ER, Lingley JK, Saldanha I, Torr SJ, Cunningham LJ
- Issue date: 2020 Nov
- Development of multiplex serological assay for the detection of human African trypanosomiasis.
- Authors: Nzou SM, Fujii Y, Miura M, Mwau M, Mwangi AW, Itoh M, Salam MA, Hamano S, Hirayama K, Kaneko S
- Issue date: 2016 Apr
- Human African trypanosomiasis: connecting parasite and host genetics.
- Authors: Garcia A, Courtin D, Solano P, Koffi M, Jamonneau V
- Issue date: 2006 Sep
- Emerging trends in the diagnosis of human African Trypanosomiasis.
- Authors: Radwanska M
- Issue date: 2010 Dec
- [Diagnosis of human African trypanosomiasis in 2001].
- Authors: Louis FJ, Buscher P, Lejon V
- Issue date: 2001