• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Trypanosomiasis/Sleeping Sickness
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Trypanosomiasis/Sleeping Sickness
    • View Item
    Jan 26, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Effectiveness of a 10-Day ...
    Size:
    151.7Kb
    Format:
    PDF
    Download
    Authors
    Schmid, C
    Richer, M
    Bilenge, C M M
    Josenando, T
    Chappuis, F
    Manthelot, C R
    Nangouma, A
    Doua, F
    Asumu, P
    Simarro, P
    Burri, C
    Show allShow less
    Affiliation
    Swiss Tropical Institute, Basel.
    Issue Date
    2005-06-01
    
    Metadata
    Show full item record
    Journal
    Journal of Infectious Diseases
    Abstract
    BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule. We demonstrate the effectiveness of this schedule in a noncontrolled, multinational drug-utilization study. METHODS: A total of 2020 patients with late-stage HAT were treated with the 10-day melarsoprol schedule in 16 centers in 7 African countries. We assessed outcome on the basis of major adverse events and the cure rate after treatment and during 2 years of follow-up. RESULTS: The cure rate 24 h after treatment was 93.9%; 2 years later, it was 86.2%. However, 49.3% of patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular eruptions was 0.8% and 6.8%, respectively. CONCLUSIONS: The 10-day treatment schedule was well implemented in the field and was effective. It reduces treatment duration, drug amount, and hospitalization costs per patient, and it increases treatment-center capacity. The shorter protocol has been recommended by the International Scientific Council for Trypanosomiasis Research and Control for the treatment of late-stage HAT caused by Trypanosoma brucei gambiense.
    Publisher
    Infectious Diseases Society of America and University of Chicago Press
    URI
    http://hdl.handle.net/10144/33073
    DOI
    10.1086/429929
    PubMed ID
    15871127
    Additional Links
    http://www.journals.uchicago.edu/toc/jid
    Language
    en
    ISSN
    0022-1899
    ae974a485f413a2113503eed53cd6c53
    10.1086/429929
    Scopus Count
    Collections
    Trypanosomiasis/Sleeping Sickness

    entitlement

    Related articles

    • Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness.
    • Authors: Bisser S, N'Siesi FX, Lejon V, Preux PM, Van Nieuwenhove S, Miaka Mia Bilenge C, Būscher P
    • Issue date: 2007 Feb 1
    • [Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda].
    • Authors: Legros D, Fournier C, Gastellu Etchegorry M, Maiso F, Szumilin E
    • Issue date: 1999 Jul
    • Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis.
    • Authors: Chappuis F, Udayraj N, Stietenroth K, Meussen A, Bovier PA
    • Issue date: 2005 Sep 1
    • Treatment of late stage sleeping sickness caused by T.b. gambiense: a new approach to the use of an old drug.
    • Authors: Blum J, Burri C
    • Issue date: 2002 Feb 9
    • Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial.
    • Authors: Burri C, Nkunku S, Merolle A, Smith T, Blum J, Brun R
    • Issue date: 2000 Apr 22
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.