The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
Weiser, Sheri D
Haberer, Jessica E
Deeks, Steven G
Bangsberg, David R
McCune, Joseph M
Martin, Jeffrey N
Hunt, Peter W
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AbstractHuman immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. The prognostic significance of this pathway in treated HIV disease is unknown.
PublisherOxford University Press
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