The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
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Byakwaga H - 2014 - The Kynurenine ...
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Authors
Byakwaga, HelenBoum, Yap
Huang, Yong
Muzoora, Conrad
Kembabazi, Annet
Weiser, Sheri D
Bennett, John
Cao, Huyen
Haberer, Jessica E
Deeks, Steven G
Bangsberg, David R
McCune, Joseph M
Martin, Jeffrey N
Hunt, Peter W
Issue Date
2014-08-01
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Show full item recordAbstract
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and other downstream catabolites that inhibit T-cell proliferation and interleukin 17 (IL-17) production. The prognostic significance of this pathway in treated HIV disease is unknown.Publisher
Oxford University PressPubMed ID
24585899Type
ArticleLanguage
enISSN
1537-6613ae974a485f413a2113503eed53cd6c53
10.1093/infdis/jiu115
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