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    Apr 19, 2021
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    Clinical Presentation of Patients with Ebola Virus Disease in Conakry, Guinea

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    Authors
    Bah, Elhadj Ibrahima
    Lamah, Marie-Claire
    Fletcher, Tom
    Jacob, Shevin T
    Brett-Major, David M
    Sall, Amadou Alpha
    Shindo, Nahoko
    Fischer, William A
    Lamontagne, Francois
    Saliou, Sow Mamadou
    Bausch, Daniel G
    Moumié, Barry
    Jagatic, Tim
    Sprecher, Armand
    Lawler, James V
    Mayet, Thierry
    Jacquerioz, Frederique A
    Baggi, María F Méndez
    Vallenas, Constanza
    Clement, Christophe
    Mardel, Simon
    Faye, Ousmane
    Faye, Oumar
    Soropogui, Baré
    Magassouba, Nfaly
    Koivogui, Lamine
    Pinto, Ruxandra
    Fowler, Robert A
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    Issue Date
    2014-11-05
    
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    Journal
    The New England Journal of Medicine
    Abstract
    Background In March 2014, the World Health Organization was notified of an outbreak of Zaire ebolavirus in a remote area of Guinea. The outbreak then spread to the capital, Conakry, and to neighboring countries and has subsequently become the largest epidemic of Ebola virus disease (EVD) to date. Methods From March 25 to April 26, 2014, we performed a study of all patients with laboratory-confirmed EVD in Conakry. Mortality was the primary outcome. Secondary outcomes included patient characteristics, complications, treatments, and comparisons between survivors and nonsurvivors. Results Of 80 patients who presented with symptoms, 37 had laboratory-confirmed EVD. Among confirmed cases, the median age was 38 years (interquartile range, 28 to 46), 24 patients (65%) were men, and 14 (38%) were health care workers; among the health care workers, nosocomial transmission was implicated in 12 patients (32%). Patients with confirmed EVD presented to the hospital a median of 5 days (interquartile range, 3 to 7) after the onset of symptoms, most commonly with fever (in 84% of the patients; mean temperature, 38.6°C), fatigue (in 65%), diarrhea (in 62%), and tachycardia (mean heart rate, >93 beats per minute). Of these patients, 28 (76%) were treated with intravenous fluids and 37 (100%) with antibiotics. Sixteen patients (43%) died, with a median time from symptom onset to death of 8 days (interquartile range, 7 to 11). Patients who were 40 years of age or older, as compared with those under the age of 40 years, had a relative risk of death of 3.49 (95% confidence interval, 1.42 to 8.59; P=0.007). Conclusions Patients with EVD presented with evidence of dehydration associated with vomiting and severe diarrhea. Despite attempts at volume repletion, antimicrobial therapy, and limited laboratory services, the rate of death was 43%.
    Publisher
    Massachusetts Medical Society
    URI
    http://hdl.handle.net/10144/336795
    DOI
    10.1056/NEJMoa1411249
    PubMed ID
    25372658
    Additional Links
    http://www.nejm.org/doi/full/10.1056/NEJMoa1411249
    Language
    en
    Description
    To access this article, click on "Additional Links".
    ISSN
    1533-4406
    ae974a485f413a2113503eed53cd6c53
    10.1056/NEJMoa1411249
    Scopus Count
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    Other Diseases

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