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dc.contributor.authorBah, Elhadj Ibrahima
dc.contributor.authorLamah, Marie-Claire
dc.contributor.authorFletcher, Tom
dc.contributor.authorJacob, Shevin T
dc.contributor.authorBrett-Major, David M
dc.contributor.authorSall, Amadou Alpha
dc.contributor.authorShindo, Nahoko
dc.contributor.authorFischer, William A
dc.contributor.authorLamontagne, Francois
dc.contributor.authorSaliou, Sow Mamadou
dc.contributor.authorBausch, Daniel G
dc.contributor.authorMoumié, Barry
dc.contributor.authorJagatic, Tim
dc.contributor.authorSprecher, Armand
dc.contributor.authorLawler, James V
dc.contributor.authorMayet, Thierry
dc.contributor.authorJacquerioz, Frederique A
dc.contributor.authorBaggi, María F Méndez
dc.contributor.authorVallenas, Constanza
dc.contributor.authorClement, Christophe
dc.contributor.authorMardel, Simon
dc.contributor.authorFaye, Ousmane
dc.contributor.authorFaye, Oumar
dc.contributor.authorSoropogui, Baré
dc.contributor.authorMagassouba, Nfaly
dc.contributor.authorKoivogui, Lamine
dc.contributor.authorPinto, Ruxandra
dc.contributor.authorFowler, Robert A
dc.date.accessioned2014-12-07T23:55:57Z
dc.date.available2014-12-07T23:55:57Z
dc.date.issued2014-11-05
dc.identifier.citationClinical Presentation of Patients with Ebola Virus Disease in Conakry, Guinea. 2014: N. Engl. J. Med.en_GB
dc.identifier.issn1533-4406
dc.identifier.pmid25372658
dc.identifier.doi10.1056/NEJMoa1411249
dc.identifier.urihttp://hdl.handle.net/10144/336795
dc.descriptionTo access this article, click on "Additional Links".en_GB
dc.description.abstractBackground In March 2014, the World Health Organization was notified of an outbreak of Zaire ebolavirus in a remote area of Guinea. The outbreak then spread to the capital, Conakry, and to neighboring countries and has subsequently become the largest epidemic of Ebola virus disease (EVD) to date. Methods From March 25 to April 26, 2014, we performed a study of all patients with laboratory-confirmed EVD in Conakry. Mortality was the primary outcome. Secondary outcomes included patient characteristics, complications, treatments, and comparisons between survivors and nonsurvivors. Results Of 80 patients who presented with symptoms, 37 had laboratory-confirmed EVD. Among confirmed cases, the median age was 38 years (interquartile range, 28 to 46), 24 patients (65%) were men, and 14 (38%) were health care workers; among the health care workers, nosocomial transmission was implicated in 12 patients (32%). Patients with confirmed EVD presented to the hospital a median of 5 days (interquartile range, 3 to 7) after the onset of symptoms, most commonly with fever (in 84% of the patients; mean temperature, 38.6°C), fatigue (in 65%), diarrhea (in 62%), and tachycardia (mean heart rate, >93 beats per minute). Of these patients, 28 (76%) were treated with intravenous fluids and 37 (100%) with antibiotics. Sixteen patients (43%) died, with a median time from symptom onset to death of 8 days (interquartile range, 7 to 11). Patients who were 40 years of age or older, as compared with those under the age of 40 years, had a relative risk of death of 3.49 (95% confidence interval, 1.42 to 8.59; P=0.007). Conclusions Patients with EVD presented with evidence of dehydration associated with vomiting and severe diarrhea. Despite attempts at volume repletion, antimicrobial therapy, and limited laboratory services, the rate of death was 43%.
dc.languageENG
dc.language.isoenen
dc.publisherMassachusetts Medical Societyen_GB
dc.relation.urlhttp://www.nejm.org/doi/full/10.1056/NEJMoa1411249en_GB
dc.rightsArchived with thanks to The New England Journal of Medicineen_GB
dc.titleClinical Presentation of Patients with Ebola Virus Disease in Conakry, Guineaen
dc.identifier.journalThe New England Journal of Medicineen_GB
html.description.abstractBackground In March 2014, the World Health Organization was notified of an outbreak of Zaire ebolavirus in a remote area of Guinea. The outbreak then spread to the capital, Conakry, and to neighboring countries and has subsequently become the largest epidemic of Ebola virus disease (EVD) to date. Methods From March 25 to April 26, 2014, we performed a study of all patients with laboratory-confirmed EVD in Conakry. Mortality was the primary outcome. Secondary outcomes included patient characteristics, complications, treatments, and comparisons between survivors and nonsurvivors. Results Of 80 patients who presented with symptoms, 37 had laboratory-confirmed EVD. Among confirmed cases, the median age was 38 years (interquartile range, 28 to 46), 24 patients (65%) were men, and 14 (38%) were health care workers; among the health care workers, nosocomial transmission was implicated in 12 patients (32%). Patients with confirmed EVD presented to the hospital a median of 5 days (interquartile range, 3 to 7) after the onset of symptoms, most commonly with fever (in 84% of the patients; mean temperature, 38.6°C), fatigue (in 65%), diarrhea (in 62%), and tachycardia (mean heart rate, >93 beats per minute). Of these patients, 28 (76%) were treated with intravenous fluids and 37 (100%) with antibiotics. Sixteen patients (43%) died, with a median time from symptom onset to death of 8 days (interquartile range, 7 to 11). Patients who were 40 years of age or older, as compared with those under the age of 40 years, had a relative risk of death of 3.49 (95% confidence interval, 1.42 to 8.59; P=0.007). Conclusions Patients with EVD presented with evidence of dehydration associated with vomiting and severe diarrhea. Despite attempts at volume repletion, antimicrobial therapy, and limited laboratory services, the rate of death was 43%.


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