Expanding Access to HIV Viral Load Testing: A Systematic Review of RNA Stability in EDTA Tubes and PPT beyond Current Time and Temperature Thresholds
Siemieniuk, Reed A
MetadataShow full item record
AbstractHIV viral load (VL) testing is the gold standard for antiretroviral treatment monitoring, but many barriers exist to VL testing in resource-limited settings, including storage and transport limitations for whole blood and plasma. Data from various studies indicate that HIV RNA is stable beyond current recommendations. We conducted a systematic review to assess stability data of HIV RNA in whole blood and plasma across times and temperatures.
PublisherPublic Library of Science
- Storage and Transportation of "HIV" RNA in Plasma Samples up to 45°C in a Lyophilized Stabilizer.
- Authors: Weidner J, Hünger F, Odaibo G, Olaleye D, Reichelt D, Greve B, Cassens U
- Issue date: 2019 Aug 1
- Stability of plasma human immunodeficiency virus load in VACUTAINER PPT plasma preparation tubes during overnight shipment.
- Authors: Holodniy M, Rainen L, Herman S, Yen-Lieberman B
- Issue date: 2000 Jan
- Effects of specimen collection, processing, and storage conditions on stability of human immunodeficiency virus type 1 RNA levels in plasma.
- Authors: Ginocchio CC, Wang XP, Kaplan MH, Mulligan G, Witt D, Romano JW, Cronin M, Carroll R
- Issue date: 1997 Nov
- Stability of HIV-1 RNA in blood during specimen handling and storage prior to amplification by NASBA-QT.
- Authors: Bruisten SM, Oudshoorn P, van Swieten P, Boeser-Nunnink B, van Aarle P, Tondreau SP, Cuypers HT
- Issue date: 1997 Sep
- Reliability of plasma HIV viral load testing beyond 24 hours: Insights gained from a study in a routine diagnostic laboratory.
- Authors: Hardie D, Korsman S, Ameer S, Vojnov L, Hsiao NY
- Issue date: 2019