• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    Jan 15, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Exploring HIV infection and susceptibility to measles among older children and adults in Malawi: a facility-based study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Polonsky.pdf
    Size:
    663.5Kb
    Format:
    PDF
    Download
    Authors
    Polonsky, Jonathan A
    Singh, Beverley
    Masiku, Charlie
    Langendorf, Céline
    Kagoli, Matthew
    Hurtado, Northan
    Berthelot, Mathilde
    Heinzelmann, Annette
    Puren, Adrian
    Grais, Rebecca F
    Issue Date
    2014-12-11
    
    Metadata
    Show full item record
    Journal
    International Journal of Infectious Diseases
    Abstract
    Background HIV infection increases measles susceptibility in infants, but little is known about this relationship among older children and adults. We conducted a facility-based study to explore whether HIV status and/or CD4 count were associated with either measles seroprotection and/or measles antibody concentration. Methods We conveniently sampled HIV-infected patients presenting for follow-up care, and HIV-uninfected individuals presenting for HIV testing at Chiradzulu District Hospital, Malawi, from January to September 2012. We recorded age, sex and reported measles vaccination and infection history. Blood samples were taken to determine CD4 count and measles antibody concentration. Results 1935 (1434 HIV-infected; 501 HIV-uninfected) participants were recruited. The majority of adults, and approximately half the children, were measles seroprotected, with lower odds among HIV-infected children (adjusted OR=0.27, 95% CI: 0.10-0.69, p=0.006), but not adults. Among HIV-infected participants, neither CD4 count (p=0.16) nor time on antiretroviral therapy (p=0.25) were associated with measles antibody concentration, while older age (p<0.001) and female sex (p<0.001) were independently associated with this measure. Conclusions We found no evidence that HIV infection contributes to the risk for measles infection among adults, but HIV-infected children (including at ages older than previously reported), were less likely to be seroprotected in this sample.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/338916
    DOI
    10.1016/j.ijid.2014.12.010
    PubMed ID
    25499042
    Language
    en
    ISSN
    1878-3511
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijid.2014.12.010
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

    Related articles

    • Measles seroprevalence in Chiradzulu district, Malawi: Implications for evaluating vaccine coverage.
    • Authors: Polonsky JA, Juan-Giner A, Hurtado N, Masiku C, Kagoli M, Grais RF
    • Issue date: 2015 Aug 26
    • Seroprevalence of measles vaccine antibody response in vertically HIV-infected children, in Morocco.
    • Authors: Haban H, Benchekroun S, Sadeq M, Tajounte L, Ahmed HJ, Benjouad A, Amzazi S, Oumzil H, Elharti E
    • Issue date: 2018 Dec 19
    • Changes in measles serostatus among HIV-infected Zambian children initiating antiretroviral therapy before and after the 2010 measles outbreak and supplemental immunization activities.
    • Authors: Rainwater-Lovett K, Nkamba HC, Mubiana-Mbewe M, Bolton-Moore C, Moss WJ
    • Issue date: 2013 Dec 1
    • Prevalence of measles antibodies in asymptomatic human immunodeficiency virus-infected adults.
    • Authors: Sha BE, Harris AA, Benson CA, Atkinson WL, Urbanski PA, Stewart JA, Williams WW, Murphy RL, Phair JP, Levin SA
    • Issue date: 1991 Nov
    • Evaluation of the immune response to a 2-dose measles vaccination schedule administered at 6 and 9 months of age to HIV-infected and HIV-uninfected children in Malawi.
    • Authors: Helfand RF, Witte D, Fowlkes A, Garcia P, Yang C, Fudzulani R, Walls L, Bae S, Strebel P, Broadhead R, Bellini WJ, Cutts F
    • Issue date: 2008 Nov 15
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.