Mycobacterium ulcerans treatment - can antibiotic duration be reduced in selected patients?

Cowan, Raquel; Athan, Eugene; Friedman, N Deborah; Hughes, Andrew J; McDonald, Anthony; Callan, Peter; Fyfe, Janet; O'Brien, Daniel P

dc.contributor.author	Cowan, Raquel
dc.contributor.author	Athan, Eugene
dc.contributor.author	Friedman, N Deborah
dc.contributor.author	Hughes, Andrew J
dc.contributor.author	McDonald, Anthony
dc.contributor.author	Callan, Peter
dc.contributor.author	Fyfe, Janet
dc.contributor.author	O'Brien, Daniel P
dc.date.accessioned	2015-03-23T19:09:58Z
dc.date.available	2015-03-23T19:09:58Z
dc.date.issued	2015-02-06
dc.identifier.citation	Mycobacterium ulcerans treatment - can antibiotic duration be reduced in selected patients? 2015, 9 (2):e0003503 PLoS Negl Trop Dis	en_GB
dc.identifier.issn	1935-2735
dc.identifier.pmid	25658304
dc.identifier.doi	10.1371/journal.pntd.0003503
dc.identifier.uri	http://hdl.handle.net/10144/347023
dc.description.abstract	Mycobacterium ulcerans (M. ulcerans) is a necrotizing skin infection endemic to the Bellarine Peninsula, Australia. Current treatment recommendations include 8 weeks of combination antibiotics, with adjuvant surgery if necessary. However, antibiotic toxicity often results in early treatment cessation and local experience suggests that shorter antibiotic courses may be effective with concurrent surgery. We report the outcomes of patients in the Barwon Health M. ulcerans cohort who received shorter courses of antibiotic therapy than 8 weeks.
dc.language.iso	en	en
dc.publisher	Public Library of Science	en_GB
dc.rights	Archived with thanks to PLoS Neglected Tropical Diseases	en_GB
dc.title	Mycobacterium ulcerans treatment - can antibiotic duration be reduced in selected patients?	en
dc.identifier.journal	PLoS Neglected Tropical Diseases	en_GB
refterms.dateFOA	2019-03-04T11:52:52Z
html.description.abstract	Mycobacterium ulcerans (M. ulcerans) is a necrotizing skin infection endemic to the Bellarine Peninsula, Australia. Current treatment recommendations include 8 weeks of combination antibiotics, with adjuvant surgery if necessary. However, antibiotic toxicity often results in early treatment cessation and local experience suggests that shorter antibiotic courses may be effective with concurrent surgery. We report the outcomes of patients in the Barwon Health M. ulcerans cohort who received shorter courses of antibiotic therapy than 8 weeks.