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    Jan 19, 2021
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    Transmission of ebola viruses: what we know and what we do not know

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    Osterholm et al - 2015 - Trans ...
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    Authors
    Osterholm, Michael T
    Moore, Kristine A
    Kelley, Nicholas S
    Brosseau, Lisa M
    Wong, Gary
    Murphy, Frederick A
    Peters, Clarence J
    LeDuc, James W
    Russell, Phillip K
    Van Herp, Michel
    Kapetshi, Jimmy
    Muyembe, Jean-Jacques T
    Ilunga, Benoit Kebela
    Strong, James E
    Grolla, Allen
    Wolz, Anja
    Kargbo, Brima
    Kargbo, David K
    Formenty, Pierre
    Sanders, David Avram
    Kobinger, Gary P
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    Issue Date
    2015-02-19
    
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    Journal
    mBio
    Abstract
    Available evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. Key areas requiring further study include (i) the role of aerosol transmission (either via large droplets or small particles in the vicinity of source patients), (ii) the role of environmental contamination and fomite transmission, (iii) the degree to which minimally or mildly ill persons transmit infection, (iv) how long clinically relevant infectiousness persists, (v) the role that "superspreading events" may play in driving transmission dynamics, (vi) whether strain differences or repeated serial passage in outbreak settings can impact virus transmission, and (vii) what role sylvatic or domestic animals could play in outbreak propagation, particularly during major epidemics such as the 2013-2015 West Africa situation. In this review, we address what we know and what we do not know about Ebola virus transmission. We also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.
    Publisher
    American Society for Microbiology
    URI
    http://hdl.handle.net/10144/347026
    DOI
    10.1128/mBio.00137-15
    PubMed ID
    25698835
    Language
    en
    ISSN
    2150-7511
    ae974a485f413a2113503eed53cd6c53
    10.1128/mBio.00137-15
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