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dc.contributor.authorOsterholm, Michael T
dc.contributor.authorMoore, Kristine A
dc.contributor.authorKelley, Nicholas S
dc.contributor.authorBrosseau, Lisa M
dc.contributor.authorWong, Gary
dc.contributor.authorMurphy, Frederick A
dc.contributor.authorPeters, Clarence J
dc.contributor.authorLeDuc, James W
dc.contributor.authorRussell, Phillip K
dc.contributor.authorVan Herp, Michel
dc.contributor.authorKapetshi, Jimmy
dc.contributor.authorMuyembe, Jean-Jacques T
dc.contributor.authorIlunga, Benoit Kebela
dc.contributor.authorStrong, James E
dc.contributor.authorGrolla, Allen
dc.contributor.authorWolz, Anja
dc.contributor.authorKargbo, Brima
dc.contributor.authorKargbo, David K
dc.contributor.authorFormenty, Pierre
dc.contributor.authorSanders, David Avram
dc.contributor.authorKobinger, Gary P
dc.date.accessioned2015-03-23T19:26:06Z
dc.date.available2015-03-23T19:26:06Z
dc.date.issued2015-02-19
dc.identifier.citationTransmission of ebola viruses: what we know and what we do not know. 2015, 6 (2): MBioen_GB
dc.identifier.issn2150-7511
dc.identifier.pmid25698835
dc.identifier.doi10.1128/mBio.00137-15
dc.identifier.urihttp://hdl.handle.net/10144/347026
dc.description.abstractAvailable evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. Key areas requiring further study include (i) the role of aerosol transmission (either via large droplets or small particles in the vicinity of source patients), (ii) the role of environmental contamination and fomite transmission, (iii) the degree to which minimally or mildly ill persons transmit infection, (iv) how long clinically relevant infectiousness persists, (v) the role that "superspreading events" may play in driving transmission dynamics, (vi) whether strain differences or repeated serial passage in outbreak settings can impact virus transmission, and (vii) what role sylvatic or domestic animals could play in outbreak propagation, particularly during major epidemics such as the 2013-2015 West Africa situation. In this review, we address what we know and what we do not know about Ebola virus transmission. We also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen_GB
dc.rightsArchived with thanks to mBioen_GB
dc.titleTransmission of ebola viruses: what we know and what we do not knowen
dc.identifier.journalmBioen_GB
refterms.dateFOA2019-03-04T11:53:11Z
html.description.abstractAvailable evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. Key areas requiring further study include (i) the role of aerosol transmission (either via large droplets or small particles in the vicinity of source patients), (ii) the role of environmental contamination and fomite transmission, (iii) the degree to which minimally or mildly ill persons transmit infection, (iv) how long clinically relevant infectiousness persists, (v) the role that "superspreading events" may play in driving transmission dynamics, (vi) whether strain differences or repeated serial passage in outbreak settings can impact virus transmission, and (vii) what role sylvatic or domestic animals could play in outbreak propagation, particularly during major epidemics such as the 2013-2015 West Africa situation. In this review, we address what we know and what we do not know about Ebola virus transmission. We also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.


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