• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    Apr 11, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Erika 1 Coetzee.pdf
    Size:
    110.4Kb
    Format:
    PDF
    Download
    Authors
    Coetzee, D
    Hildebrand, K
    Boulle, A
    Maartens, G
    Louis, F
    Labatala, V
    Reuter, H
    Ntwana, N
    Goemaere, E
    Affiliation
    Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, South Africa.
    Issue Date
    2004-04-09
    
    Metadata
    Show full item record
    Journal
    AIDS (London, England)
    Abstract
    BACKGROUND: A community-based antiretroviral therapy (ART) programme was established in 2001 in a South African township to explore the operational issues involved in providing ART in the public sector in resource-limited settings and demonstrate the feasibility of such a service. METHODS: Data was analysed on a cohort of patients with symptomatic HIV disease and a CD4 lymphocyte count < 200 x 10 cells/l. The programme used standardized protocols (using generic medicines whenever possible), a team-approach to clinical care and a patient-centred approach to promote adherence. RESULTS: Two-hundred and eighty-seven adults naive to prior ART were followed for a median duration of 13.9 months. The median CD4 lymphocyte count was 43 x 10 cells/l at initiation of treatment, and the mean log10 HIV RNA was 5.18 copies/ml. The HIV RNA level was undetectable (< 400 copies/ml) in 88.1, 89.2, 84.2, 75.0 and 69.7% of patients at 3, 6, 12, 18 and 24 months respectively. The cumulative probability of remaining alive was 86.3% at 24 months on treatment for all patients, 91.4% for those with a baseline CD4 lymphocyte count > or =50 x 10 cells/l, and 81.8% for those with a baseline CD4 lymphocyte count < 50 x 10 cells/l. The cumulative probability of changing a single antiretroviral drug by 24 months was 15.1% due to adverse events or contraindications, and 8.4% due to adverse events alone. CONCLUSIONS: ART can be provided in resource-limited settings with good patient retention and clinical outcomes. With responsible implementation, ART is a key component of a comprehensive response to the epidemic in those communities most affected by HIV.
    URI
    http://hdl.handle.net/10144/38956
    PubMed ID
    15060436
    Language
    en
    ISSN
    0269-9370
    Collections
    HIV/AIDS

    entitlement

    Related articles

    • Long-term adherence to antiretroviral therapy in a South African adult patient cohort: a retrospective study.
    • Authors: Moosa A, Gengiah TN, Lewis L, Naidoo K
    • Issue date: 2019 Sep 5
    • Rapid scale-up of a community-based HIV treatment service: programme performance over 3 consecutive years in Guguletu, South Africa.
    • Authors: Bekker LG, Myer L, Orrell C, Lawn S, Wood R
    • Issue date: 2006 Apr
    • Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa.
    • Authors: Boulle A, Van Cutsem G, Hilderbrand K, Cragg C, Abrahams M, Mathee S, Ford N, Knight L, Osler M, Myers J, Goemaere E, Coetzee D, Maartens G
    • Issue date: 2010 Feb 20
    • Twelve-year mortality in adults initiating antiretroviral therapy in South Africa.
    • Authors: Cornell M, Johnson LF, Wood R, Tanser F, Fox MP, Prozesky H, Schomaker M, Egger M, Davies MA, Boulle A, International Epidemiology Databases to Evaluate AIDS-Southern Africa collaboration.
    • Issue date: 2017 Sep 25
    • Improved long-term antiretroviral treatment outcomes amongst patients receiving community-based adherence support in South Africa.
    • Authors: Fatti G, Mothibi E, Shaikh N, Grimwood A
    • Issue date: 2016 Nov
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.