Rapid culture-based methods for drug-resistance detection in Mycobacterium tuberculosis.
Affiliation
Mycobacteriology Unit, Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerp, Belgium.Issue Date
2008-10
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Show full item recordAbstract
Tuberculosis still represents a major public health problem, especially in low-resource countries where the burden of the disease is more important. Multidrug-resistant and extensively drug drug-resistant tuberculosis constitute serious problems for the efficient control of the disease stressing the need to investigate resistance to first- and second-line drugs. Conventional methods for detecting drug-resistance in Mycobacterium tuberculosis are slow and cumbersome. The most commonly used proportion method on Löwenstein-Jensen medium or Middlebrook agar requires a minimum of 3-4 weeks to produce results. Several new approaches have been proposed in the last years for the rapid and timely detection of drug-resistance in tuberculosis. This review will address phenotypic culture-based methods for rapid drug susceptibility testing in M. tuberculosis.Publisher
ElsevierPubMed ID
18627779Additional Links
http://www.sciencedirect.com/science/journal/01677012.Language
enISSN
0167-7012ae974a485f413a2113503eed53cd6c53
10.1016/j.mimet.2008.06.015
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