The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria.
AuthorsLee, S J
Binh, T Q
de Vries, P J
Guthmann, J P
White, N J
AffiliationMahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420/6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand. firstname.lastname@example.org
MetadataShow full item record
AbstractBACKGROUND: Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS: Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. RESULTS: A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (+/- SD) of -0.69 (+/- 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). CONCLUSION: Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid.
- Haemoglobin and haematocrit: is the threefold conversion valid for assessing anaemia in malaria-endemic settings?
- Authors: Carneiro IA, Drakeley CJ, Owusu-Agyei S, Mmbando B, Chandramohan D
- Issue date: 2007 May 22
- Haemoglobin and haematocrit: the threefold conversion is also non valid for assessing anaemia in Plasmodium vivax malaria-endemic settings.
- Authors: Rodríguez-Morales AJ, Sánchez E, Arria M, Vargas M, Piccolo C, Colina R, Franco-Paredes C
- Issue date: 2007 Dec 17
- Relationship between haemoglobin and haematocrit in the definition of anaemia.
- Authors: Quintó L, Aponte JJ, Menéndez C, Sacarlal J, Aide P, Espasa M, Mandomando I, Guinovart C, Macete E, Hirt R, Urassa H, Navia MM, Thompson R, Alonso PL
- Issue date: 2006 Aug
- Age as a risk factor for thrombocytopenia and anaemia in children treated for acute uncomplicated falciparum malaria.
- Authors: Adedapo AD, Falade CO, Kotila RT, Ademowo GO
- Issue date: 2007 Dec
- A country-wide malaria survey in Mozambique. I. Plasmodium falciparum infection in children in different epidemiological settings.
- Authors: Mabunda S, Casimiro S, Quinto L, Alonso P
- Issue date: 2008 Oct 24