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    Jan 26, 2021
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    Efficacy and safety of dihydroartemisinin-piperaquine.

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    Authors
    Myint, H Y
    Ashley, E A
    Day, N P J
    Nosten, F
    White, N J
    Affiliation
    Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand.
    Issue Date
    2007-09
    Submitted date
    2009-03-04
    
    Metadata
    Show full item record
    Journal
    Transactions of the Royal Society of Tropical Medicine and Hygiene
    Abstract
    Dihydroartemisinin-piperaquine, a fixed-dose combination antimalarial, is an inexpensive, safe and highly effective treatment for uncomplicated falciparum or vivax malaria. Efficacy assessed over 28-63 days has consistently exceeded 95% in the treatment of multidrug-resistant falciparum malaria. More than 2600 patients have been treated with this combination in prospective studies, mainly in Southeast Asia. Tolerability was uniformly good, and no serious adverse effects have been identified. The dosing regimen has been simplified from four doses to once daily over 3 days. More information on efficacy in Africa, and more pharmacokinetic and efficacy data in children are needed.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/52374
    DOI
    10.1016/j.trstmh.2007.05.018
    PubMed ID
    17659311
    Additional Links
    http://www.sciencedirect.com/science/journal/00359203
    Type
    Article
    Language
    en
    ISSN
    0035-9203
    Sponsors
    Epicentre
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.trstmh.2007.05.018
    Scopus Count
    Collections
    Malaria

    entitlement

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