Affiliation
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand.Issue Date
2007-09Submitted date
2009-03-04
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Show full item recordAbstract
Dihydroartemisinin-piperaquine, a fixed-dose combination antimalarial, is an inexpensive, safe and highly effective treatment for uncomplicated falciparum or vivax malaria. Efficacy assessed over 28-63 days has consistently exceeded 95% in the treatment of multidrug-resistant falciparum malaria. More than 2600 patients have been treated with this combination in prospective studies, mainly in Southeast Asia. Tolerability was uniformly good, and no serious adverse effects have been identified. The dosing regimen has been simplified from four doses to once daily over 3 days. More information on efficacy in Africa, and more pharmacokinetic and efficacy data in children are needed.Publisher
ElsevierPubMed ID
17659311Additional Links
http://www.sciencedirect.com/science/journal/00359203Type
ArticleLanguage
enISSN
0035-9203Sponsors
Epicentreae974a485f413a2113503eed53cd6c53
10.1016/j.trstmh.2007.05.018
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