• Global Burden of Rheumatic Heart Disease

      Rossi, G (Massachusetts Medical Society, 2018-01-04)
    • Non-communicable diseases - programmatic and clinical guidelines

      Jobanputra, Kiran; Manson Unit, MSF UK, London (2016-12)
    • Peripheral Neuropathy in a Diabetic Child Treated with Linezolid for Multidrug-Resistant Tuberculosis: A Case Report and Review of the Literature

      Swaminathan, A; du Cros, P; Seddon, J; Mirgayosieva, S; Asladdin, R; Dusmatova, Z (BioMed Central, 2017-06-12)
      Extensively drug-resistant (XDR) tuberculosis (TB) and multidrug resistant (MDR)-TB with additional resistance to injectable agents or fluoroquinolones are challenging to treat due to lack of available, effective drugs. Linezolid is one of the few drugs that has shown promise in treating these conditions. Long-term linezolid use is associated with toxicities such as peripheral and optic neuropathies. Diabetes mellitus (DM), especially when uncontrolled, can also result in peripheral neuropathy. The global burden of DM is increasing, and DM has been associated with a three-fold increased risk of developing TB disease. TB and DM can be a challenging combination to treat. DM can inhibit the host immune response to tuberculosis infection; and TB and some anti-TB drugs can worsen glycaemic control. A child experiencing neuropathy that is a possible complication of both DM and linezolid used to treat TB has not been reported previously. We report peripheral neuropathy in a 15-year-old boy with type 1 DM, diagnosed with MDR-TB and additional resistance to injectable TB medications.
    • Prevalence of non-communicable diseases and access to care among non-camp Syrian refugees in northern Jordan

      Rehr, M; Shoaib, M; Ellithy, S; Okour, S; Ariti, C; Ait-Bouziad, I; van den Bosch, P; Deprade, A; Altarawneh, M; Shafei, A; et al. (BioMed Central, 2018-07-11)
      Tackling the high non-communicable disease (NCD) burden among Syrian refugees poses a challenge to humanitarian actors and host countries. Current response priorities are the identification and integration of key interventions for NCD care into humanitarian programs as well as sustainable financing. To provide evidence for effective NCD intervention planning, we conducted a cross-sectional survey among non-camp Syrian refugees in northern Jordan to investigate the burden and determinants for high NCDs prevalence and NCD multi-morbidities and assess the access to NCD care.
    • Sickle cell disease in anaemic children in a Sierra Leonean district hospital: a case series.

      Italia, MB; Kirolos, S (Oxford University Press, 2019-07-12)
      Sickle cell disease (SCD) is the most common inherited haemoglobinopathy wordwide, with the highest prevalence in sub-Saharan Africa. Due to the lack of national strategies and scarcity of diagnostic tools in resource-limited settings, the disease may be significantly underdiagnosed. We carried out a 6-month retrospective review of paediatric admissions in a district hospital in northern Sierra Leone. Our aim was to identify patients with severe anaemia, defined as Hb < 7 g/dl, and further analyse the records of those tested for SCD. Of the 273 patients identified, only 24.5% had had an Emmel test, among which 34.3% were positive. Furthermore, only 17% of patients with a positive Emmel test were discharged on prophylactic antibiotics. Our study shows that increased awareness of SCD symptoms is required in high-burden areas without established screening programmes. In addition, the creation or strengthening of follow-up programmes for SCD patients is essential for disease control.
    • Task Shifting the Management of Non-Communicable Diseases to Nurses in Kibera, Kenya: Does It Work?

      Some, D; Edwards, J K; Reid, T; Van den Bergh, R; Kosgei, R J; Wilkinson, E; Baruani, B; Kizito, W; Khabala, K; Shah, S; et al. (Public Library of Science, 2016-01-26)
      In sub-Saharan Africa there is an increasing need to leverage available health care workers to provide care for non-communicable diseases (NCDs). This study was conducted to evaluate adherence to Médecins Sans Frontières clinical protocols when the care of five stable NCDs (hypertension, diabetes mellitus type 2, epilepsy, asthma, and sickle cell) was shifted from clinical officers to nurses.
    • Three Steps to Improve Management of Noncommunicable Diseases in Humanitarian Crises

      Jobanputra, K; Boulle, P; Roberts, B; Perel, P (Public Library of Science, 2016-11-08)
      Kiran Jobanputra and colleagues argue that better evidence, guidance, and tools are needed to improve the effectiveness and feasibility of noncommunicable disease care in humanitarian settings.