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    Jan 17, 2021
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    Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings

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    Murphy R et al - 2015- Challenges ...
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    Authors
    Murphy, Richard A
    Gounder, Lilishia
    Manzini, Thandekile C
    Ramdial, Pratistadevi K
    Castilla, Carmen
    Moosa, Mahomed-Yunus S
    Issue Date
    2015-03-30
    
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    Journal
    Open Forum Infectious Diseases
    Abstract
    The diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and the unavailability of sensitive diagnostics including antigen assays. Treatment options are also limited due to the unavailability of liposomal amphotericin and itraconazole, and the inability to perform therapeutic drug monitoring further confounds management. We present 3 clinical cases to illustrate the limits of diagnosis and management in the southern African context, and we highlight the need for additional diagnostic tools and treatment options in resource-limited settings.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/560491
    DOI
    10.1093/ofid/ofv025
    PubMed ID
    26034774
    Language
    en
    ISSN
    2328-8957
    ae974a485f413a2113503eed53cd6c53
    10.1093/ofid/ofv025
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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