Challenges in the management of disseminated progressive histoplasmosis in human immunodeficiency virus-infected patients in resource-limited settings
Authors
Murphy, Richard AGounder, Lilishia
Manzini, Thandekile C
Ramdial, Pratistadevi K
Castilla, Carmen
Moosa, Mahomed-Yunus S
Issue Date
2015-03-30
Metadata
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Open Forum Infectious DiseasesAbstract
The diagnosis of histoplasmosis in patients with human immunodeficiency virus in southern Africa is complicated by the nonspecific presentation of the disease in this patient group and the unavailability of sensitive diagnostics including antigen assays. Treatment options are also limited due to the unavailability of liposomal amphotericin and itraconazole, and the inability to perform therapeutic drug monitoring further confounds management. We present 3 clinical cases to illustrate the limits of diagnosis and management in the southern African context, and we highlight the need for additional diagnostic tools and treatment options in resource-limited settings.Publisher
Oxford University PressPubMed ID
26034774Language
enISSN
2328-8957ae974a485f413a2113503eed53cd6c53
10.1093/ofid/ofv025
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