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    Mar 02, 2021
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    The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014

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    Authors
    Fitzpatrick, Gabriel
    Vogt, Florian
    Gbabai, Osman B Moi
    Decroo, Tom
    Keane, Marian
    De Clerck, Hilde
    Grolla, Allen
    Brechard, Raphael
    Stinson, Kathryn
    Van Herp, Michel
    Issue Date
    2015-05-22
    
    Metadata
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    Journal
    The Journal of Infectious Diseases
    Abstract
    This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died. These findings highlight the importance viral load at admission has on mortality outcomes and could be used to cohort cases with viral loads greater than 10 million copies into dedicated wards with more intensive medical support to further reduce mortality.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/560498
    DOI
    10.1093/infdis/jiv304
    PubMed ID
    26002981
    Language
    en
    ISSN
    1537-6613
    ae974a485f413a2113503eed53cd6c53
    10.1093/infdis/jiv304
    Scopus Count
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    Other Diseases

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