Show simple item record

dc.contributor.authorCox, H
dc.contributor.authorFurin, J J
dc.contributor.authorMitnick, C D
dc.contributor.authorDaniels, C
dc.contributor.authorCox, V
dc.contributor.authorGoemaere, E
dc.date.accessioned2015-07-21T22:50:21Z
dc.date.available2015-07-21T22:50:21Z
dc.date.issued2015-07-01
dc.identifier.citationThe need to accelerate access to new drugs for multidrug-resistant tuberculosis. 2015, 93 (7):491-7 Bull. World Health Organ.en_GB
dc.identifier.issn1564-0604
dc.identifier.pmid26170507
dc.identifier.doi10.2471/BLT.14.138925
dc.identifier.urihttp://hdl.handle.net/10144/560858
dc.description.abstractApproximately half a million people are thought to develop multidrug-resistant tuberculosis annually. Barely 20% of these people currently receive recommended treatment and only about 10% are successfully treated. Poor access to treatment is probably driving the current epidemic, via ongoing transmission. Treatment scale-up is hampered by current treatment regimens, which are lengthy, expensive, poorly tolerated and difficult to administer in the settings where most patients reside. Although new drugs provide an opportunity to improve treatment regimens, current and planned clinical trials hold little promise for developing regimens that will facilitate prompt treatment scale-up. In this article we argue that clinical trials, while necessary, should be complemented by timely, large-scale, operational research that will provide programmatic data on the use of new drugs and regimens while simultaneously improving access to life-saving treatment. Perceived risks - such as the rapid development of resistance to new drugs - need to be balanced against the high levels of mortality and transmission that will otherwise persist. Doubling access to treatment and increasing treatment success could save approximately a million lives over the next decade.
dc.language.isoenen
dc.publisherWorld Health Organizationen_GB
dc.rightsArchived with thanks to Bulletin of the World Health Organizationen_GB
dc.titleThe Need to Accelerate Access to New Drugs for Multidrug-resistant Tuberculosisen
dc.identifier.journalBulletin of the World Health Organizationen_GB
refterms.dateFOA2019-03-04T12:31:19Z
html.description.abstractApproximately half a million people are thought to develop multidrug-resistant tuberculosis annually. Barely 20% of these people currently receive recommended treatment and only about 10% are successfully treated. Poor access to treatment is probably driving the current epidemic, via ongoing transmission. Treatment scale-up is hampered by current treatment regimens, which are lengthy, expensive, poorly tolerated and difficult to administer in the settings where most patients reside. Although new drugs provide an opportunity to improve treatment regimens, current and planned clinical trials hold little promise for developing regimens that will facilitate prompt treatment scale-up. In this article we argue that clinical trials, while necessary, should be complemented by timely, large-scale, operational research that will provide programmatic data on the use of new drugs and regimens while simultaneously improving access to life-saving treatment. Perceived risks - such as the rapid development of resistance to new drugs - need to be balanced against the high levels of mortality and transmission that will otherwise persist. Doubling access to treatment and increasing treatment success could save approximately a million lives over the next decade.


Files in this item

Thumbnail
Name:
Cox H et al - 2015 - The Need ...
Size:
602.7Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record